Soler F, Fernandez-Belda F, Gomez-Fernandez J C
Departamento de Bioquimica y Biologia Molecular, Universidad de Murcia, Spain.
Biochem Biophys Res Commun. 1988 Mar 30;151(3):1093-8. doi: 10.1016/s0006-291x(88)80478-9.
The apparent effect of tetraphenylboron on the Ca2+-dependent ATPase activity is rather complex being dependent of the physical state of the membrane. In leaky vesicles, tetraphenylboron decreases the affinity of the enzyme for Ca2+, and high concentrations (100 microM) inhibit the enzyme. These effects are mediated by the membrane structure. In native vesicles, tetraphenylboron induces an apparent stimulation of the maximum hydrolytic activity and a decrease of the Ca2+ gradient formed due to specific Ca2+ releasing activity of the mentioned drug.
