University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States.
H. Lee Moffitt Cancer Center, University of South Florida Morsani College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612-9497, United States.
Int J Infect Dis. 2018 Jul;72:1-2. doi: 10.1016/j.ijid.2018.04.004. Epub 2018 Apr 12.
Vaccines containing live attenuated bacterial or viral organisms are currently being investigated as potential therapy for locally advanced or metastatic cancers. However, the use of such live organisms in an immunocompromised population, such as patients who recently or are currently receiving chemotherapy, raises the concern that these organisms can themselves disseminate and cause frank infection. We report a hereunto unreported phenomenon of anti-cancer vaccines (containing live attenuated organisms) leading to frank, disseminated infection. We submit that occurrence of this phenomenon must be watched for by all members of the interdisciplinary cancer treatment team.
目前，含有减毒活细菌或病毒的疫苗正被作为局部晚期或转移性癌症的潜在治疗方法进行研究。然而，在免疫功能低下的人群（如最近或正在接受化疗的患者）中使用此类活生物体引起了人们的担忧，即这些生物体本身可能会传播并导致明显感染。我们报告了一种迄今为止尚未报道的现象，即抗癌疫苗（含减毒活生物体）导致明显的、播散性感染。我们认为，这种现象的发生必须引起肿瘤多学科治疗团队所有成员的关注。
