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过氧化物酶 1 高表达与胃癌上皮-间质转化标志物相关，并与不良预后相关。

High Expression of Peroxiredoxin 1 Is Associated with Epithelial-Mesenchymal Transition Marker and Poor Prognosis in Gastric Cancer.

机构信息

Department of Gastrointestinal Surgery, Anhui Provincial Cancer Hospital, Hefei, Anhui, China (mainland).

Department of Pathology, Anhui Provincial Cancer Hospital, Hefei, Anhui, China (mainland).

出版信息

Med Sci Monit. 2018 Apr 15;24:2259-2270. doi: 10.12659/msm.908722.

DOI:10.12659/msm.908722
PMID:29656298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917825/
Abstract

BACKGROUND Recent studies show that peroxiredoxin 1 (Prdx1) contributes to the progression and poor prognosis of carcinoma through multiple mechanisms. However, there is little information on its expression and prognostic value in gastric cancer. This study investigated the expression of Prdx1 in gastric cancer, along with evaluating its clinical-pathological and prognostic importance. MATERIAL AND METHODS A total of 189 pairs of gastric cancer and paracarcinomatous tissues were assessed for Prdx1 expression and its association with clinical characteristics. The molecular mechanism was further investigated through in vitro experimentation. RESULTS The mRNA and protein levels of Prdx1 in the GC tissues were higher than in the peri-tumor tissues. We also found that high Prdx1 expression was positively correlated with the lymph node invasion and poor prognosis. It also served as an autonomous prognostic factor for patients with gastric cancer. Moreover, Prdx1 regulates the invasion and metastasis of GC cell lines through inhibiting E-Ca expression. CONCLUSIONS Prdx1 can promote epithelial-mesenchymal transition and gastric cancer progression. Therefore, it might be a therapeutic target and prognostic indicator for gastric cancer patients.

摘要

背景

最近的研究表明，过氧化物酶 1（Prdx1）通过多种机制促进癌的进展和不良预后。然而，关于其在胃癌中的表达和预后价值的信息很少。本研究调查了 Prdx1 在胃癌中的表达情况，并评估了其临床病理和预后意义。

材料和方法

评估了 189 对胃癌和癌旁组织中 Prdx1 的表达及其与临床特征的关系。通过体外实验进一步研究了分子机制。

结果

GC 组织中 Prdx1 的 mRNA 和蛋白水平高于癌旁组织。我们还发现，高 Prdx1 表达与淋巴结浸润和不良预后呈正相关。它还是胃癌患者自主预后因素。此外，Prdx1 通过抑制 E-Ca 表达调节 GC 细胞系的侵袭和转移。

结论

Prdx1 可促进上皮-间充质转化和胃癌进展。因此，它可能是胃癌患者的治疗靶点和预后指标。

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