氨甲环酸在全髋关节置换术中的应用：随机对照试验和队列研究的混合治疗比较
Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies.
作者信息
Sridharan Kannan, Sivaramakrishnan Gowri
机构信息
Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.
School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
出版信息
J Orthop. 2018 Jan 17;15(1):81-88. doi: 10.1016/j.jor.2018.01.051. eCollection 2018 Mar.
Abstract
BACKGROUND
The present study is a network meta-analysis of various routes of tranexamic acid (TXA) in patients with total hip arthroplasty (THA).
METHODS
Randomized controlled trials and cohort studies evaluating TXA in patients with THA were included. Number of patients requiring blood transfusion was the primary outcome.
RESULTS
Pooled estimate for TXA use against placebo for blood transfusion rate was 0.30 [0.23, 0.39] favoring TXA. Maximum reduction in the risk of blood transfusion was observed with topical plus intra-operative intravenous TXA.
CONCLUSION
Combined topical and intravenous TXA during surgery may perform better than other modes in patients undergoing THA.
摘要
背景
本研究是对全髋关节置换术（THA）患者中氨甲环酸（TXA）不同给药途径的网络荟萃分析。
方法
纳入评估THA患者使用TXA的随机对照试验和队列研究。输血患者数量为主要结局指标。
结果
TXA与安慰剂相比，输血率的合并估计值为0.30[0.23, 0.39]，表明TXA更具优势。局部联合术中静脉注射TXA时，输血风险降低幅度最大。
结论
在接受THA的患者中，手术期间联合局部和静脉注射TXA可能比其他给药方式效果更好。
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本文引用的文献
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2
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