Grzybowska-Chlebowczyk Urszula, Jasielska Martyna, Flak-Wancerz Anna, Więcek Sabina, Gruszczyńska Katarzyna, Chlebowczyk Wojciech, Woś Halina
Department of Paediatrics, School of Medicine, Medical University of Silesia, Katowice, Poland.
Department of Gastroenterology, Upper-Silesian Child Health Care Centre, Katowice, Poland.
Prz Gastroenterol. 2018;13(1):69-75. doi: 10.5114/pg.2017.70470. Epub 2017 Dec 27.
The acute pancreatitis is a rare disease, but it has started to be diagnosed more often in children.
The aim of the study was single-centre, retrospective analysis of the incidence, aetiology, and clinical course of acute pancreatitis in children.
We analysed the medical records of patients with acute pancreatitis hospitalised in the Gastroenterology Unit of the Paediatrics Department, Medical University of Silesia from Jan 2004 to Dec 2013.
There were 76 cases of acute pancreatitis among 51 children (average age: 12.07 years) hospitalised in the Gastroenterology Unit between January 2004 and December 2013. The diagnosis of acute pancreatitis was performed on the basis of INSPIRE criteria and modified Atlanta classification. Patients were divided into groups: I - 1-12 years old, which included 20 (39.21%) children and II - 13-18 years old, with 31 (60.78%) children. The idiopathic aetiology was the most common cause of acute pancreatitis, occurring in 22 (43.1%) children, and in 15 cases the aetiology of the disease was biliary (29.4%). Genetically determined causes were diagnosed in 8 (15.7%) patients, the mutation in four patients, mutation in in 1 child, and gene mutation in 1 child. Two children simultaneously had two genes mutations (, ), and during the considered period had more than one episode of acute pancreatitis.
Acute pancreatitis of idiopathic aetiology was most common among the examined children, and this should encourage the continued search for the causes of disease, especially genetic, and with particular emphasis on younger age group.
急性胰腺炎是一种罕见疾病，但在儿童中其诊断率开始上升。
本研究旨在对儿童急性胰腺炎的发病率、病因及临床病程进行单中心回顾性分析。
我们分析了2004年1月至2013年12月在西里西亚医科大学儿科胃肠病科住院的急性胰腺炎患者的病历。
2004年1月至2013年12月间，胃肠病科收治的51名儿童（平均年龄：12.07岁）中有76例急性胰腺炎病例。急性胰腺炎的诊断依据INSPIRE标准和改良的亚特兰大分类法进行。患者分为两组：I组为1 - 12岁，包括20名（39.21%）儿童；II组为13 - 18岁，有31名（60.78%）儿童。特发性病因是急性胰腺炎最常见的原因，22名（43.1%）儿童为此病因，15例疾病病因是胆汁性的（29.4%）。8名（15.7%）患者被诊断为基因决定的病因，4名患者存在 突变，1名儿童存在 突变，1名儿童存在 基因突变。两名儿童同时有两种基因突变（ ， ），且在研究期间发生了不止一次急性胰腺炎发作。
特发性病因的急性胰腺炎在受检儿童中最为常见，这应促使继续寻找疾病病因，尤其是基因方面的病因，特别要关注较年轻年龄组。
