Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zhejiang Provincial Key Laboratory of Pulsed Electric Field Technology Medical Transformation, Hangzhou, Zhejiang, China.
Pediatr Res. 2022 Jan;91(1):56-63. doi: 10.1038/s41390-021-01454-1. Epub 2021 Mar 19.
For children, there are very few published reviews focusing on severe acute pancreatitis (AP). PubMed, EMBASE, Web of Science, Scopus, Chinese National Knowledge Infrastructure (CNKI), Wanfang data, EBSCO, and Cochrane Library were searched from inception until March 2020. Meta-regression analyses were used to estimate the etiology, case fatality, recurrence, and severity of pediatric AP in different regions (North America, Asia, South America, Europe, and Oceania). Pooled data from 47 papers (48 studies) found that main causes of pediatric AP were gallstones in Asia; trauma in Oceania; and idiopathic in Europe, North America, and South America. The case-fatality rate (CFR) of pediatric AP is 4.7% (North America), 6.2% (Europe), 2.4% (Asia), 3.1% (South America), and 7.4% (Oceania). The incidence rates of recurrent acute pancreatitis (RAP) in children who have had an episode of acute pancreatitis in North American, Asia, and Europe were 15.3, 13.1, and 13.8%, respectively. The incidence of severe acute pancreatitis (SAP) in different regions was 30.3% (Oceania), 29.2% (South America), 20.8% (Europe), 15.8% (Asia), and 13.7% (North America). It suggests that physicians should notice the etiology of pediatric AP for the initial assessment, diagnosis, prediction of relapse, and appropriate treatment at a later stage. IMPACT: It indicates the etiology of pediatric acute pancreatitis for the initial assessment, diagnosis, and prediction of relapse. Main causes of pediatric AP were gallstones in Asia; trauma in Oceania; and idiopathic in Europe, North America, and South America. The case-fatality rate of pediatric AP is diverse worldwide. It suggests that physicians noticed the etiology of pediatric AP for the initial assessment, diagnosis, prediction of relapse, and appropriate treatment at a later stage.
对于儿童，很少有针对重症急性胰腺炎（AP）的已发表综述。从创建到 2020 年 3 月，我们在 PubMed、EMBASE、Web of Science、Scopus、中国知网（CNKI）、万方数据、EBSCO 和 Cochrane Library 上进行了搜索。使用荟萃回归分析来估计不同地区（北美、亚洲、南美、欧洲和大洋洲）儿科 AP 的病因、病死率、复发率和严重程度。来自 47 篇论文（48 项研究）的汇总数据发现，亚洲儿童 AP 的主要病因是胆石症；大洋洲的创伤；欧洲、北美和南美则是特发性。儿科 AP 的病死率（CFR）为 4.7%（北美）、6.2%（欧洲）、2.4%（亚洲）、3.1%（南美）和 7.4%（大洋洲）。在经历过急性胰腺炎发作的北美、亚洲和欧洲儿童中，复发性急性胰腺炎（RAP）的发生率分别为 15.3%、13.1%和 13.8%。不同地区 SAP 的发生率分别为 30.3%（大洋洲）、29.2%（南美）、20.8%（欧洲）、15.8%（亚洲）和 13.7%（北美）。这表明医生应注意儿科 AP 的病因，以便在初始评估、诊断、预测复发和后续的适当治疗。影响：它为儿科急性胰腺炎的初始评估、诊断和复发预测提供了病因。亚洲儿童 AP 的主要病因是胆石症；大洋洲的创伤；欧洲、北美和南美则是特发性。儿科 AP 的病死率在全球范围内存在差异。这表明医生应注意儿科 AP 的病因，以便在初始评估、诊断、预测复发和后续的适当治疗。
