Ghobrial Fady Emil Ibrahim, Eldin Manal Salah, Razek Ahmed Abdel Khalek Abdel, Atwan Nadia Ibrahim, Shamaa Sameh Sayed Ahmed
Department of Internal Medicine (Medical Oncology), Faculty of Medicine, Oncology Center Mansoura University, Mansoura, Egypt.
Department of Diagnostic Radiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Pol J Radiol. 2017 Oct 20;82:593-597. doi: 10.12659/PJR.902930. eCollection 2017.
To assess inter-observer agreement of revised RECIST criteria (version 1.1) for computed tomography assessment of hepatic metastases of breast cancer.
MATERIAL/METHODS: A prospective study was conducted in 28 female patients with breast cancer and with at least one measurable metastatic lesion in the liver that was treated with 3 cycles of anthracycline-based chemotherapy. All patients underwent computed tomography of the abdomen with 64-row multi- detector CT at baseline and after 3 cycles of chemotherapy for response assessment. Image analysis was performed by 2 observers, based on the RECIST criteria (version 1.1).
Computed tomography revealed partial response of hepatic metastases in 7 patients (25%) by one observer and in 10 patients (35.7%) by the other observer, with good inter-observer agreement (k=0.75, percent agreement of 89.29%). Stable disease was detected in 19 patients (67.8%) by one observer and in 16 patients (57.1%) by the other observer, with good agreement (k=0.774, percent agreement of 89.29%). Progressive disease was detected in 2 patients (7.2%) by both observers, with perfect agreement (k=1, percent agreement of 100%). The overall inter-observer agreement in the CT-based response assessment of hepatic metastasis between the two observers was good (=0.793, percent agreement of 89.29%).
We concluded that computed tomography is a reliable and reproducible imaging modality for response assessment of hepatic metastases of breast cancer according to the RECIST criteria (version 1.1).
评估修订后的RECIST标准（1.1版）用于乳腺癌肝转移计算机断层扫描评估时观察者间的一致性。
材料/方法：对28例患有乳腺癌且肝脏至少有一个可测量转移灶的女性患者进行了一项前瞻性研究，这些患者接受了3个周期的蒽环类化疗。所有患者在基线时和化疗3个周期后均接受64排多层螺旋CT腹部扫描以评估疗效。由2名观察者根据RECIST标准（1.1版）进行图像分析。
一名观察者通过计算机断层扫描发现7例患者（25%）的肝转移有部分缓解，另一名观察者发现10例患者（35.7%）有部分缓解，观察者间一致性良好（k=0.75，一致性百分比为89.29%）。一名观察者在19例患者（67.8%）中检测到疾病稳定，另一名观察者在16例患者（57.1%）中检测到疾病稳定，一致性良好（k=0.774，一致性百分比为89.29%）。两名观察者均在2例患者（7.2%）中检测到疾病进展，一致性完美（k=1，一致性百分比为100%）。两名观察者在基于CT的肝转移疗效评估中的总体观察者间一致性良好（=0.793，一致性百分比为89.29%）。
我们得出结论，根据RECIST标准（1.1版），计算机断层扫描是用于乳腺癌肝转移疗效评估的一种可靠且可重复的成像方式。
