Nurttila Sandra S, Linnebank Pim R, Krachko Tetiana, Reek Joost N H
Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
ACS Catal. 2018 Apr 6;8(4):3469-3488. doi: 10.1021/acscatal.8b00288. Epub 2018 Mar 9.
The hydroformylation reaction is one of the most intensively explored reactions in the field of homogeneous transition metal catalysis, and many industrial applications are known. However, this atom economical reaction has not been used to its full potential, as many selectivity issues have not been solved. Traditionally, the selectivity is controlled by the ligand that is coordinated to the active metal center. Recently, supramolecular strategies have been demonstrated to provide powerful complementary tools to control activity and selectivity in hydroformylation reactions. In this review, we will highlight these supramolecular strategies. We have organized this paper in sections in which we describe the use of supramolecular bidentate ligands, substrate preorganization by interactions between the substrate and functional groups of the ligands, and hydroformylation catalysis in molecular cages.
氢甲酰化反应是均相过渡金属催化领域中研究最为深入的反应之一，并且已知有许多工业应用。然而，由于许多选择性问题尚未解决，这种原子经济反应尚未得到充分利用。传统上，选择性由与活性金属中心配位的配体控制。最近，超分子策略已被证明是控制氢甲酰化反应活性和选择性的强大补充工具。在这篇综述中，我们将重点介绍这些超分子策略。我们将本文分为几个部分，在这些部分中，我们描述了超分子双齿配体的使用、底物与配体官能团之间的相互作用对底物的预组织作用以及分子笼中的氢甲酰化催化作用。
