下一代测序在肿瘤放射敏感性预测中的作用。
The role of Next-Generation Sequencing in tumoral radiosensitivity prediction.
作者信息
Bibault Jean-Emmanuel, Tinhofer Ingeborg
机构信息
Radiation Oncology Department, Georges Pompidou European Hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris Sorbonne Cité, Paris, France.
INSERM UMR 1138 Team 22: Information Sciences to Support Personalized Medicine, Paris Descartes University, Sorbonne Paris Cité, Paris, France.
出版信息
Clin Transl Radiat Oncol. 2017 Apr 9;3:16-20. doi: 10.1016/j.ctro.2017.03.002. eCollection 2017 Apr.
Technological advances have led to more precise radiation delivery, which has resulted in significant clinical gains. A better understanding of tumoral radiosensitivity is still needed to develop strategies and further personalize radiation treatments. Next-Generation Sequencing (NGS) and system biology have significantly transformed the field of oncology in the last two decades, but have only a few clinical applications in radiation oncology. This review describes the technical aspects and evolutions of NGS and discusses the latest clinical applications of genomics to predict tumoral radiosensitivity.
技术进步带来了更精确的放射治疗，从而取得了显著的临床成效。然而，仍需要更好地了解肿瘤放射敏感性，以制定策略并进一步实现放射治疗的个性化。在过去二十年中，新一代测序（NGS）和系统生物学极大地改变了肿瘤学领域，但在放射肿瘤学中的临床应用却寥寥无几。本综述描述了NGS的技术方面和进展，并讨论了基因组学在预测肿瘤放射敏感性方面的最新临床应用。
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