Dolgikh O V, Zaitseva N V, Nosov A E, Krivtsov A V, Dianova D G, Kazakova O A, Otavina E A, Alikina I N
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia.
Perm State National Research University, Perm, Russia.
Bull Exp Biol Med. 2018 Apr;164(6):753-756. doi: 10.1007/s10517-018-4073-2. Epub 2018 Apr 16.
We studied the role of the carrier status for polymorphic loci of genes encoding estrogen receptors (ESR1), endothelial NO synthase (eNOS), and apolipoprotein E (APOE4) and products of their expression nitrogen oxide (NO) and apolipoprotein (ApoE) in the development of arterial hypertension in men. Conventionally healthy volunteers and 149 men with clinical manifestations of stage I-II arterial hypertension were examined. In men with arterial hypertension, the frequency of minor allele A of ESR1 gene was higher (27.5 vs. 9.5% in the reference group; χ=4.43, p=0.04). The level of NO in the peripheral blood was also higher in the main group (χ=3.93, p=0.047). The increase in NO concentration did not depend on the presence of polymorphic genotypes (GG and GT) of eNOS gene, but the decrease in ApoE level in blood serum was associated with TC genotype of APOE4 gene (p=0.04). Our results suggest that minor allele A of ESR1 gene is associated with the development of arterial hypertension in men. Reduced content of ApoE in blood serum of men with arterial hypertension was associated with APOE4 gene polymorphism. However, increased level of NO did not depend on polymorphic genotypes GG and GT of eNOS gene. These polymorphisms are of specific interest as additional markers of genetic predisposition to the development of arterial hypertension in middle-age men.
我们研究了雌激素受体（ESR1）、内皮型一氧化氮合酶（eNOS）和载脂蛋白E（APOE4）编码基因多态性位点的携带者状态及其表达产物一氧化氮（NO）和载脂蛋白（ApoE）在男性动脉高血压发生发展中的作用。对常规健康志愿者和149例有I-II期动脉高血压临床表现的男性进行了检查。在患有动脉高血压的男性中，ESR1基因的次要等位基因A的频率更高（参考组为9.5%，而病例组为27.5%；χ=4.43，p=0.04）。主要组外周血中的NO水平也更高（χ=3.93，p=0.047）。NO浓度的升高不依赖于eNOS基因多态性基因型（GG和GT）的存在，但血清中ApoE水平的降低与APOE4基因的TC基因型相关（p=0.04）。我们的结果表明，ESR1基因的次要等位基因A与男性动脉高血压的发生有关。患有动脉高血压的男性血清中ApoE含量的降低与APOE4基因多态性有关。然而，NO水平的升高不依赖于eNOS基因的多态性基因型GG和GT。这些多态性作为中年男性动脉高血压发生遗传易感性的附加标志物具有特殊意义。
