Li Ting, LIu Wen, Yang Si-Jie, Zhang Chen, Xie Nan, Li Shi-Jun, Gao Xuan
Center for Reproductive Medicine / National Research Center for Assisted Reproductive Technology and Reproductive Genetics / Key Laboratory for Reproductive Endocrinology of the Ministry of Education, Shandong University, Jinan, Shandong 250001, China.
.
Zhonghua Nan Ke Xue. 2017 Jan;23(1):57-60.
To investigate the routine semen parameters and sperm morphological indexes of the patients with partial globozoospermia (PGZ).
We included in this study 100 infertile males with PGZ and another 180 non-PGZ infertile men as controls. According to the proportion of round-headed sperm (RHS) in the semen, we classified the PGZ males into five subgroups: 25%－40%, 41%－55%, 56%－70%, 71%－85%, and 86%－99% RHS. We obtained sperm concentration, total sperm motility, the percentage of progressively motile sperm, teratozoospermia index (TZI), and sperm deformity index (SDI) from the subjects and compared them among different groups.
Statistically significant differences were found between the PGZ patients and non-PGZ controls in total sperm motility (［35.76±24.88］% vs ［62.03±10.20］%, P<0.01), the percentage of progressively motile sperm (［26.11±20.39］% vs ［45.62±6.87］%, P<0.01), the percentage of morphologically normal sperm (［1.45±1.45］% vs ［5.98±2.21］%, P<0.01), and SDI (1.33±0.11 vs 1.27±0.57, P<0.01), but not in age (［29.82±4.90］ vs ［30.33±3.59 ］ yr, P>0.05), sperm concentration (［46.01±40.38］ vs ［54.00±25.15］ ×106/ml, P>0.05), or TZI (1.35±0.11 vs 1.34±0.54, P>0.05). There were also significant differences among the five PGZ subgroups in total sperm motility, progressive sperm motility, normal sperm morphology, TZI, and SDI (P<0.01), but not in age or sperm concentration (P>0.05). Morphologically, the sperm head changed from heterogeneous to homogeneous with the increased proportion of round-headed sperm.
Different proportions of round-headed sperm are closely related to routine semen parameters and sperm morphological index in PGZ patients, which can help clinicians choose the proper assisted reproductive technology and predict the rate of fertilization for infertile males.
探讨部分圆头精子症（PGZ）患者的常规精液参数及精子形态学指标。
本研究纳入100例PGZ不育男性及另外180例非PGZ不育男性作为对照。根据精液中圆头精子（RHS）的比例，将PGZ男性分为五个亚组：RHS占25%－40%、41%－55%、56%－70%、71%－85%和86%－99%。我们获取了受试者的精子浓度、总精子活力、前向运动精子百分比、畸形精子指数（TZI）和精子畸形指数（SDI），并在不同组间进行比较。
PGZ患者与非PGZ对照组在总精子活力（［35.76±24.88］%对［62.03±10.20］%，P<0.01）、前向运动精子百分比（［26.11±20.39］%对［45.62±6.87］%，P<0.01）、形态正常精子百分比（［1.45±1.45］%对［5.98±2.21］%，P<0.01）和SDI（1.33±0.11对1.27±0.57，P<0.01）方面存在统计学显著差异，但在年龄（［29.82±4.90］对［30.33±3.59］岁，P>0.05）、精子浓度（［46.01±I40.38］对［54.00±25.15］×106/ml，P>0.05）或TZI（1.35±0.11对1.3±0.54，P>0.05）方面无差异。五个PGZ亚组在总精子活力、前向运动精子活力、正常精子形态、TZI和SDI方面也存在显著差异（P<0.01），但在年龄或精子浓度方面无差异（P>0.05）。形态学上，随着圆头精子比例增加，精子头部从异质性变为均质性。
PGZ患者中不同比例的圆头精子与常规精液参数及精子形态学指标密切相关，这有助于临床医生为不育男性选择合适的辅助生殖技术并预测受精率。
