Cormier C, Menkès C J, Chevrot A, Amor B
Service de Rhumatologie "A", Hôpital Cochin, Paris.
Rev Rhum Mal Osteoartic. 1988 Feb;55(2):83-5.
The retrospective study of the first 67 patients treated by chemonucleolysis, since December 1980, shows a good overall result, in 69 p. cent of the cases (40 patients) and a failure in 31 p. cent of the cases (18 patients), with a 42 months follow-up. The radiculalgia is cured or quite improved in one month in 90 p. cent of the cases and in 2 years in 88 p. cent. Lumbalgia is absent or moderate after 1 month in 58 p. cent of the cases and after 2 years in 81 p. cent. It persists, most of the time, in women, and this is statistically significant. 15 immediate failures and 3 recurrent sciaticas at the same level are noticed after a 22 months free interval. The possibility of severe complications requires a perfect technique and well-defined indications. The study confirms the good results of nucleolysis with a 42 months follow-up.
对自1980年12月起接受化学溶核术治疗的首批67例患者进行的回顾性研究显示，经过42个月的随访，总体效果良好，69%（40例患者）的病例取得了良好效果，31%（18例患者）的病例治疗失败。90%的病例在1个月内神经根痛得到治愈或显著改善，88%的病例在2年内得到改善。58%的病例在1个月后腰痛消失或减轻，81%的病例在2年后如此。大多数情况下，腰痛在女性中持续存在，且具有统计学意义。在22个月的无病间隔期后，发现有15例即刻失败病例和3例同一水平复发性坐骨神经痛病例。严重并发症的可能性要求具备完善的技术和明确的适应症。该研究证实了化学溶核术在42个月随访期内的良好效果。
