Sidiropoulos D, Wegmann G, Bütler R, von Muralt G
Abteilung für Perinatologie der Universitäts-Frauenklinik Bern.
Schweiz Med Wochenschr. 1988 Mar 5;118(9):309-12.
Screening for hepatitis Bs antigen in late pregnancy was introduced in mid-1983 at the University Women's Hospital, Berne. 4118 pregnant women had been investigated by the end of 1986, of whom 26 (0.63%) turned out to be HBsAg positive. The prevalence of HBsAg carriers was 0.12% in Swiss women, 0.65% in other European women, 12.5% in women from the Far East and 5.6% and 4.9% in women from the Near East and Africa respectively. Newborns of HBsAg positive mothers simultaneously received hepatitis B immunoglobulin (400 IU anti-HBs) and a first injection of hepatitis B vaccine (Hevac B 5 mg) in the first hours of life, followed by vaccinations after two, three and twelve months. Of 18 children investigated after the first year of life none was HBsAg positive. 14 children (78%) were shown to have HBs antibodies. Two of the four anti-HBs-negative unfortunately received only the first vaccine injection after birth. Taking this fact into account, the "success rate" of the immunoprophylaxis is 88%.
1983年年中，伯尔尼大学妇女医院开始在妊娠晚期进行乙肝表面抗原筛查。到1986年底，共对4118名孕妇进行了调查，其中26名（0.63%）被证明乙肝表面抗原呈阳性。乙肝表面抗原携带者的患病率在瑞士妇女中为0.12%，在其他欧洲妇女中为0.65%，在远东妇女中为12.5%，在近东和非洲妇女中分别为5.6%和4.9%。乙肝表面抗原阳性母亲所生的新生儿在出生后的头几个小时内同时接受乙肝免疫球蛋白（400 IU抗-HBs）和第一剂乙肝疫苗（Hevac B 5 mg），随后在两个月、三个月和十二个月时进行疫苗接种。在一岁后接受调查的18名儿童中，没有一名乙肝表面抗原呈阳性。14名儿童（78%）被证明有乙肝抗体。四名抗-HBs阴性的儿童中，有两名不幸仅在出生后接受了第一剂疫苗注射。考虑到这一事实，免疫预防的“成功率”为88%。
