a Global Medical Affairs , Baxter Healthcare Corporation , Deerfield , IL , USA.
b Global Medical Affairs , Magni Consulting Group , Woodland Hills , CA , USA.
Expert Rev Med Devices. 2018 May;15(5):367-376. doi: 10.1080/17434440.2018.1464909. Epub 2018 Apr 26.
Intraoperative surgical sealants and hemostatic agents have been shown to reduce postoperative complications, transfusions, and hospital resource utilization. Despite availability of these agents, the incidence and burden of bleeding remains high and surgeons' requirements for hemostatic control continue to evolve. A burgeoning class of hemostatic agents are hemostatic patches, which offer package-to-patient readiness and direct application. In addition, hemostatic patches may provide tissue sealing capabilities. Areas covered: This review focuses on the clinical effectiveness, versatility, and surgical efficiency of HEMOPATCH as a surgical sealant and hemostatic agent in various surgical specialties including: cardiac, digestive (hepatic, gastrointestinal, pancreatic), urological, neurological, and endocrine. Expert commentary: Among hemostatic patches, HEMOPATCH is a valuable tool to stop bleeding without adverse events across various surgical specialties. Clinical evidence demonstrates the safety, clinical effectiveness, and versatility of HEMOPATCH as a unique surgical adjunct in patients undergoing complex and routine surgical procedures. Larger randomized-controlled clinical studies, or clinical registries, will continue to be used to evaluate its performance and versatility, particularly for sealing tissues and closing the dura. In the current field of surgical sealing and hemostasis, however, HEMOPATCH represents the next step in improving patient outcomes.
术中使用的外科密封剂和止血剂已被证明可以减少术后并发症、输血和医院资源的利用。尽管有这些制剂可用,但出血的发生率和负担仍然很高,外科医生对止血控制的需求也在不断发展。一类新兴的止血剂是止血贴,它具有即用即包装和直接应用的特点。此外,止血贴还可能具有组织密封的能力。涵盖领域:本综述重点关注 HEMOPATCH 作为一种外科密封剂和止血剂在包括心脏、消化(肝脏、胃肠道、胰腺)、泌尿科、神经科和内分泌科等多个外科专业中的临床效果、多功能性和手术效率。专家评论:在止血贴中,HEMOPATCH 是一种在各种外科专业中止血而无不良事件的有价值的工具。临床证据表明,HEMOPATCH 作为一种独特的外科辅助工具,在接受复杂和常规手术的患者中具有安全性、临床效果和多功能性。更大规模的随机对照临床试验或临床登记将继续用于评估其性能和多功能性,特别是在密封组织和闭合硬脑膜方面。然而,在当前的外科密封和止血领域,HEMOPATCH 代表了改善患者预后的下一步。