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兔膝关节软骨蛋白聚糖降解后血清硫酸角质素水平升高。

Increase in levels of serum keratan sulfate following cartilage proteoglycan degradation in the rabbit knee joint.

作者信息

Williams J M, Downey C, Thonar E J

机构信息

Department of Anatomy, Rush Medical College, Chicago, Illinois 60612.

出版信息

Arthritis Rheum. 1988 Apr;31(4):557-60. doi: 10.1002/art.1780310415.

DOI:10.1002/art.1780310415
PMID:2965877
Abstract

Following injection of chymopapain into a single knee joint in rabbits, serum keratan sulfate levels rose sharply and remained elevated for at least 48 hours before returning to preinjection levels. These changes were accompanied by depletion of proteoglycans from articular cartilage in the injected joint. We conclude that serum keratan sulfate levels rise predictably following acute loss of proteoglycan from a single joint.

摘要

向兔的单个膝关节注射木瓜凝乳蛋白酶后，血清硫酸角质素水平急剧上升，并在至少48小时内保持升高，然后才恢复到注射前水平。这些变化伴随着注射关节的关节软骨中蛋白聚糖的消耗。我们得出结论，单个关节蛋白聚糖急性丢失后，血清硫酸角质素水平会出现可预测的升高。

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