Center for Oncological Research, University of Antwerp, Antwerp, Belgium; Cancer Immunotherapy and Immune Innovation Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia.
Dept of Hepatobiliary, Endocrine and Transplantation Surgery, Antwerp University Hospital, Antwerp, Belgium.
Pharmacol Ther. 2018 Sep;189:31-44. doi: 10.1016/j.pharmthera.2018.04.003. Epub 2018 Apr 13.
Pancreatic cancer is among the three deadliest cancers worldwide with the lowest 5-year survival of all cancers. Despite all efforts, therapeutic improvements have barely been made over the last decade. Even recent highly promising targeted and immunotherapeutic approaches did not live up to their expectations. Therefore, other horizons have to be explored. Natural Killer (NK) cells are gaining more and more interest as a highly attractive target for cancer immunotherapies, both as pharmaceutical target and for cell therapies. In this systematic review we summarise the pathophysiological adaptions of NK cells in pancreatic cancer and highlight possible (future) therapeutic NK cell-related targets. Furthermore, an extensive overview of recent therapeutic approaches with an effect on NK cells is given, including cytokine-based, viro- and bacteriotherapy and cell therapy. We also discuss ongoing clinical trials that might influence NK cells. In conclusion, although several issues regarding NK cells in pancreatic cancer remain unsolved and need further investigation, extensive evidence is already provided that support NK cell oriented approaches in pancreatic cancer.
胰腺癌是全球三种最致命的癌症之一，所有癌症中 5 年生存率最低。尽管做出了各种努力，但在过去十年中，治疗效果几乎没有改善。即使是最近非常有前途的靶向和免疫治疗方法也没有达到预期效果。因此，必须探索其他领域。自然杀伤 (NK) 细胞作为癌症免疫疗法的一个极具吸引力的靶点，无论是作为药物靶点还是细胞疗法，都越来越受到关注。在本系统综述中，我们总结了 NK 细胞在胰腺癌中的病理生理适应，并强调了可能的（未来）治疗性 NK 细胞相关靶点。此外，还广泛概述了最近对 NK 细胞有影响的治疗方法，包括细胞因子、病毒和细菌治疗以及细胞治疗。我们还讨论了正在进行的可能影响 NK 细胞的临床试验。总之，尽管胰腺癌中 NK 细胞仍存在一些未解决的问题，需要进一步研究，但已经有大量证据支持针对胰腺癌的 NK 细胞方法。
