大鼠中枢给予心房利钠多肽对生长激素分泌的刺激作用。

Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat.

作者信息

Murakami Y, Kato Y, Tojo K, Inoue T, Yanaihara N, Imura H

机构信息

Second Medical Clinic, Department of Medicine, Kyoto University Faculty of Medicine, Japan.

出版信息

Endocrinology. 1988 May;122(5):2103-8. doi: 10.1210/endo-122-5-2103.

DOI:10.1210/endo-122-5-2103

PMID:2966063

Abstract

Intracerebroventricular (icv) injection of alpha-human atrial natriuretic polypeptide (alpha hANP) or alpha-rat ANP (0.6 and 3 nmol/rat) elicited an increase in plasma GH levels both in conscious freely moving rats and in urethane-anesthetized rats when given at the trough of spontaneous GH secretion. Antiserum specific for rat GRF did not affect the plasma GH increase induced by icv injection of alpha hANP. Intracerebroventricular injection of alpha ANP (3 nmol/rat) failed to stimulate GH secretion in conscious rats pretreated with cysteamine (30 mg/100 g BW, sc), a depletor of somatostatin (SRIF), and in conscious rats during constant iv infusion of SRIF (55 ng/ml). GH release induced by iv injection of synthetic rat GRF (200 ng/100 g BW) was exaggerated by alpha hANP (3 nmol/rat, icv) in conscious rats. These results suggest that central ANP stimulates pituitary GH secretion possibly by inhibiting SRIF release from the hypothalamus in the rat.

摘要

在清醒自由活动的大鼠和氨基甲酸乙酯麻醉的大鼠中，当在生长激素（GH）自发分泌的低谷期给予时，脑室内（icv）注射α-人心房钠尿肽（α-hANP）或α-大鼠ANP（0.6和3 nmol/大鼠）可引起血浆GH水平升高。对大鼠生长激素释放因子（GRF）特异的抗血清不影响icv注射α-hANP诱导的血浆GH升高。脑室内注射α-ANP（3 nmol/大鼠）未能刺激用半胱胺（30 mg/100 g体重，皮下注射）预处理的清醒大鼠（半胱胺是一种生长抑素（SRIF）耗竭剂）以及在持续静脉输注SRIF（55 ng/ml）期间的清醒大鼠的GH分泌。在清醒大鼠中，静脉注射合成大鼠GRF（200 ng/100 g体重）诱导的GH释放被α-hANP（3 nmol/大鼠，icv）夸大。这些结果表明，在大鼠中，中枢性ANP可能通过抑制下丘脑SRIF的释放来刺激垂体GH分泌。