Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Department of Traditional Chinese Medicine, Taipei City Hospital RenAi Branch, Taipei, Taiwan.
Clin Hemorheol Microcirc. 2018;69(3):371-381. doi: 10.3233/CH-170295.
There is an urgent need to improve the early diagnosis of breast cancer.
The present study applied spectral and beat-to-beat analyses to laser-Doppler (LDF) data sequences measured on the skin surface on the back of the right hands, with the aim of comparing the different peripheral microcirculatory-blood-flow (MBF) perfusion condition between breast-cancer and control subjects.
ECG and LDF signals were obtained simultaneously and noninvasively from 23 breast-cancer patients and 23 age-matched control subjects. Time-domain beat-to-beat indexes and their variability parameters were calculated. Spectral indexes were calculated using the Morlet wavelet transform.
The beat-to-beat LDF pulse width and its variability were significantly smaller in cancer patients than in the controls. The energy contributions of endothelial-, neural-, and myogenic-related frequency bands were also significantly smaller in cancer patients.
The present study has revealed significant differences in the beat-to-beat and spectral indexes of skin-surface-acquired LDF signals between control subjects and breast-cancer patients. This illustrates that LDF indexes may be useful for monitoring the changes in the MBF perfusion condition induced by breast cancer. Since the breast-cancer patients were at TNM stages 0- 2, the present findings may aid the development of indexes for detecting breast cancer.
迫切需要提高乳腺癌的早期诊断水平。
本研究应用光谱和拍频分析方法对右手背部皮肤表面的激光多普勒（LDF）数据序列进行分析，旨在比较乳腺癌患者和对照组之间不同的外周微循环血液灌注条件。
从 23 名乳腺癌患者和 23 名年龄匹配的对照组中同时非侵入性地获得心电图（ECG）和 LDF 信号。计算时域拍频的逐搏指标及其可变性参数。使用 Morlet 小波变换计算光谱指标。
与对照组相比，癌症患者的 LDF 脉冲宽度及其可变性明显较小。与对照组相比，内皮、神经和肌源性相关频带的能量贡献也明显较小。
本研究揭示了对照组和乳腺癌患者之间皮肤表面获得的 LDF 信号的逐搏和光谱指标存在显著差异。这表明 LDF 指标可能有助于监测乳腺癌引起的 MBF 灌注条件的变化。由于乳腺癌患者处于 TNM 分期 0-2 期，本研究结果可能有助于开发用于检测乳腺癌的指标。
