1 Lloyd L Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, FL, USA.
Ann Pharmacother. 2018 Sep;52(9):936-941. doi: 10.1177/1060028018772579. Epub 2018 Apr 17.
Immunization is the best strategy to protect individuals from influenza; however, older adults tend to respond less favorably to vaccines because of immunosenescence. The Centers for Disease Control and Prevention states that any licensed, recommended, and age-appropriate influenza vaccine may be used in older adults despite reasonable evidence suggesting that the high-dose and, to a lesser extent, the adjuvanted and recombinant influenza vaccines provide better protection than the standard-dose vaccines in this vulnerable population. In this era of precision medicine, clinicians can preferentially recommend these contemporary vaccines to equip their older patients with the best possible protection against influenza.
免疫接种是保护个人免受流感影响的最佳策略；然而，老年人对疫苗的反应往往不太理想，这是由于免疫衰老。美国疾病控制与预防中心表示，尽管有合理的证据表明，高剂量疫苗，在较小程度上，佐剂和重组流感疫苗比标准剂量疫苗在这个脆弱人群中提供更好的保护，但在老年人中可以使用任何已批准、推荐和适合年龄的流感疫苗。在精准医学时代，临床医生可以优先推荐这些现代疫苗，使他们的老年患者尽可能得到最好的流感保护。
