The Dermatology Centre, Salford Royal NHS Foundation Trust, Salford, Greater Manchester, UK; Centre for Dermatology Research, University of Manchester, MAHSC and NIHR Manchester Biomedical Research Centre, Manchester, UK.
Mediteknia Dermatology Clinic and Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.
Trends Mol Med. 2018 May;24(5):435-448. doi: 10.1016/j.molmed.2018.03.007. Epub 2018 Apr 13.
Inflammation-associated, irreversible damage to epithelial stem cells (eSCs) of the hair follicle in their immunologically privileged niche lies at the heart of scarring alopecia, which causes permanent difficult-to-treat hair loss. We propose that the two most common and closely related forms, lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA), provide excellent model diseases for studying the biology and pathology of adult human eSCs in an easily accessible human mini-organ. Emphasising the critical roles for interferon (IFN)-γ and peroxisome proliferator-activated receptor (PPAR)-γ-mediated signalling in immune privilege (IP) collapse and epithelial-mesenchymal transition (EMT) of these eSCs respectively, we argue that these pathways deserve therapeutic targeting in the future management of LPP/FFA and other eSC diseases associated with IP collapse and EMT.
炎症相关的、不可逆的毛囊上皮干细胞（eSCs）损伤，发生在它们免疫特惠性龛位中，这是瘢痕性脱发的核心，导致永久性的、难以治疗的脱发。我们提出，两种最常见且密切相关的形式，即扁平苔藓性瘢痕性脱发（LPP）和额部纤维性脱发（FFA），为研究成人人类 eSCs 的生物学和病理学提供了极好的模型疾病，因为它们在易于获得的人类小型器官中存在。强调干扰素（IFN）-γ和过氧化物酶体增殖物激活受体（PPAR）-γ介导的信号通路在免疫特惠性（IP）崩溃和这些 eSCs 的上皮-间充质转化（EMT）中的关键作用，我们认为这些通路在 LPP/FFA 及其他与 IP 崩溃和 EMT 相关的 eSC 疾病的未来治疗中值得靶向治疗。
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