Jouet J P, Buchet-Bouverne B, Fenaux P, Pollet J P, Simon M, Walter M P, Leroy J L, Puech F, Delecour M, Bauters F
Service des Maladies du Sang, Hôpital Claude Huriez, Lille.
Presse Med. 1988 Mar 12;17(9):423-7.
This retrospective study concerns 13 patients in whom Hodgkin's disease was diagnosed during pregnancy or immediately after delivery (group I) and 12 patients with Hodgkin's disease who had one or several pregnancies while under treatment (group II). In group I, Hodgkin's disease was diagnosed in early pregnancy in 4 patients who all had therapeutic abortion: 3 remain in prolonged complete remission and 1 had a late relapse; 9 cases were diagnosed in late pregnancy or after delivery: 3 were treatment failures, 2 had a relapse and 4 remain in complete remission. In group II patients, 3 pregnancies occurred during initial chemotherapy and were interrupted; 5 pregnancies occurred during subsequent radiotherapy or (for earlier patients) maintenance chemotherapy, and 4 of them were interrupted; 9 pregnancies occurred within 2 years of completing treatment, and 7 after 2 years. Of the 12 patients in group II, only 2 had a relapse whereas 10 remain in complete remission. Although they should be interpreted with caution, these data suggest that Hodgkin's disease diagnosed in late pregnancy or after delivery might be more active, and they justify therapeutic abortion when diagnosis is made in early pregnancy. They do not indicate a high risk of relapse in treated Hodgkin's disease patients during a subsequent pregnancy, even if it occurs shortly after treatment.
这项回顾性研究涉及13例在孕期或分娩后立即被诊断为霍奇金病的患者（I组）以及12例在治疗期间经历过一次或多次妊娠的霍奇金病患者（II组）。在I组中，4例患者在妊娠早期被诊断为霍奇金病，她们均接受了治疗性流产：3例仍处于长期完全缓解状态，1例出现晚期复发；9例在妊娠晚期或分娩后被诊断：3例治疗失败，2例复发，4例仍处于完全缓解状态。在II组患者中，3次妊娠发生在初始化疗期间并被终止；5次妊娠发生在随后的放疗期间或（对于早期患者）维持化疗期间，其中4次被终止；9次妊娠发生在完成治疗后的2年内，7次发生在2年后。在II组的12例患者中，只有2例复发，而10例仍处于完全缓解状态。尽管这些数据应谨慎解读，但它们表明妊娠晚期或分娩后诊断出的霍奇金病可能更具活性，并且当在妊娠早期做出诊断时，治疗性流产是合理的。它们并未表明接受治疗的霍奇金病患者在随后妊娠期间有高复发风险，即使妊娠发生在治疗后不久。
