Farahmand Maryam, Ramezani Tehrani Fahimeh, Bahri Khomami Mahnaz, Azizi Fereidoun
Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Arch Iran Med. 2017 Dec 1;20(12):734-739.
To compare metabolic changes in 3 groups of postmenopausal women: those who had undergone bilateral salpingooophorectomy + hysterectomy (BSO + H), those with hysterectomy ± unilateral salpingo-oophorectomy (H ± USO), and those who reached natural menopause during follow-up.
This longitudinal study was performed on 543 female participants of the Tehran Lipid and Glucose Study (TLGS) who experienced surgical menopause (BSO + H or H ± USO) or natural menopause over a 12-year period. During the follow-up period, changes in metabolic and biochemical profiles were compared between surgically and naturally menopausal women (NMW). In all groups, data was collected using questionnaires twice, at baseline and again after 3 years.
Considering the women with natural menopause as the reference group, the odds ratio of metabolic syndrome was 5.0 in the surgically menopause due to BSO + H. Mean fasting blood glucose was also significantly higher in the H ± USO group, compared to the naturally menopausal, after adjustment for confounding variables.
The incidence of metabolic syndrome in the BSO + H group and that of fasting blood glucose in the H ± USO group were higher than NMW.
比较三组绝经后女性的代谢变化：接受双侧输卵管卵巢切除术+子宫切除术（BSO+H）的女性、接受子宫切除术±单侧输卵管卵巢切除术（H±USO）的女性以及在随访期间自然绝经的女性。
对德黑兰脂质与葡萄糖研究（TLGS）的543名女性参与者进行了这项纵向研究，她们在12年期间经历了手术绝经（BSO+H或H±USO）或自然绝经。在随访期间，比较了手术绝经和自然绝经女性（NMW）的代谢和生化指标变化。在所有组中，通过问卷调查在基线和3年后再次收集数据。
以自然绝经女性作为参照组，因BSO+H导致手术绝经的女性患代谢综合征的比值比为5.0。在调整混杂变量后，H±USO组的平均空腹血糖也显著高于自然绝经女性。
BSO+H组的代谢综合征发病率以及H±USO组的空腹血糖发病率均高于自然绝经女性。
