肝素诱导的 tau 纤维在结构上具有异质性，且不同于阿尔茨海默病纤维。
Heparin-induced tau filaments are structurally heterogeneous and differ from Alzheimer's disease filaments.
机构信息
Department of chemistry, University of California Santa Babara, Santa Barbara, California 93106, USA.
出版信息
Chem Commun (Camb). 2018 May 1;54(36):4573-4576. doi: 10.1039/c8cc01355a.
PMID:29664486
Abstract
Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.
摘要
阿尔茨海默病（AD）的特征是大脑中存在 tau 纤维，其结构最近已被阐明。AD 纤维的形成通常通过将 tau 与肝素混合在体外进行模拟。本研究表明，肝素诱导的 tau 纤维与 AD 纤维明显不同，具有高度异质性。
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