Nakayama Satoshi, Oda Tomohiro, Minabe Shinya, Bamba Yukiharu, Ukawa Haruko, Sato Rika, Kawabata Masaki, Horiuchi Toshikatsu, Watanabe Junichi, Kimura Fumihiko, Shimazaki Hideyuki, Ogata Sho, Nakanishi Kuniaki
Department of Laboratory Medicine, National Defense Medical College Hospital, Tokorozawa, Japan.
Department of Pathology and Cytology, PCL Japan, Inc., Kawagoe, Japan.
Arch Iran Med. 2018 Jan 1;21(1):41-43.
Primary nonsecretory plasma cell leukemia (PCL) is an extremely rare type of multiple myeloma. Here, we report a case of nonsecretory PCL with no previous history of multiple myeloma. The case exhibited extremely low levels of serum immunoglobulin and light chain, no detectable serum M-protein or free light chain restriction, no urine BJP, and no cytoplasmic light chain expression in flow cytometry. In fluorescence in situ hybridization, tumor cells exhibited fusion genes for IgH/BCL1 and IgH/cMyc, disappearance of the p53 signal, and a split signal for IgK(2p11), but no split signal for IgL (22q11). Therefore, we diagnosed primary nonsecretory PCL with multiple chromosomal abnormalities.
原发性非分泌性浆细胞白血病（PCL）是一种极其罕见的多发性骨髓瘤类型。在此，我们报告一例既往无多发性骨髓瘤病史的非分泌性PCL病例。该病例血清免疫球蛋白和轻链水平极低，未检测到血清M蛋白或游离轻链受限，无尿本周蛋白，流式细胞术中无细胞质轻链表达。在荧光原位杂交中，肿瘤细胞表现出IgH/BCL1和IgH/cMyc融合基因、p53信号消失以及IgK（2p11）的分裂信号，但IgL（22q11）无分裂信号。因此，我们诊断该病例为伴有多种染色体异常的原发性非分泌性PCL。
