Colorectal Surgical Unit, Aarhus University Hospital, Denmark.
Surgical Department, Regional Hospital Randers, Denmark.
Dis Colon Rectum. 2018 Jun;61(6):656-666. doi: 10.1097/DCR.0000000000001064.
Sexual dysfunction and impaired quality of life is a potential side effect to rectal cancer treatment.
The objective of this study was to develop and validate a simple scoring system intended to evaluate sexual function in women treated for rectal cancer.
This is a population-based cross-sectional study.
Female patients diagnosed with rectal cancer between 2001 and 2014 were identified by using the Danish Colorectal Cancer Group's database. Participants filled in the validated Sexual Function Vaginal Changes questionnaire. Women declared to be sexually active at follow-up were randomly assigned to 2 groups: one for development and one for validation. Logistic regression analyses identified items for the score, and multivariate analysis established a weighted-score value allocated to each item, adding up to the total score. The validity of the score was tested in the validation group.
Female patients with rectal cancer above the age of 18 who underwent abdominoperineal resection, Hartmann procedure, or total/partial mesorectal excision were selected.
The primary outcome measured was the quality of life that was negatively affected because of sexual problems.
A total of 466 sexually active women responded. The score includes 7 items with a range of 0 to 29 points. Score ≥9 indicates sexual dysfunction. The score has a sensitivity/specificity of 76%/75% detecting patients bothered by sexual dysfunction with a negative impact on quality of life.
This study was limited by the large amount of nonresponders.
Living up to our demands for a short and easy-to-use validated tool, we have developed the Rectal Cancer Female Sexuality score. It captures, with high sensitivity, the essential problems of female sexuality seen from the perspective of a surviving rectal cancer patient. See Video Abstract at http://links.lww.com/DCR/A576.
性功能障碍和生活质量受损是直肠癌治疗的潜在副作用。
本研究旨在开发和验证一种简单的评分系统，用于评估接受直肠癌治疗的女性的性功能。
这是一项基于人群的横断面研究。
通过丹麦结直肠癌组的数据库确定 2001 年至 2014 年间诊断为直肠癌的女性患者。参与者填写经过验证的性功能阴道变化问卷。在随访时声明有性行为的女性被随机分配到 2 组：一组用于开发，一组用于验证。逻辑回归分析确定了评分项目，多变量分析确定了分配给每个项目的加权评分值，加起来得到总分。在验证组中测试了评分的有效性。
选择年龄在 18 岁以上接受腹会阴切除术、Hartmann 手术或全/部分直肠系膜切除术的直肠癌女性患者。
主要测量的结果是因性问题而受到负面影响的生活质量。
共有 466 名有性行为的女性做出回应。该评分包括 7 个项目，范围为 0 至 29 分。得分≥9 表示性功能障碍。该评分的敏感性/特异性为 76%/75%，可检测出因性功能障碍而感到困扰且生活质量受到负面影响的患者。
本研究受到大量未应答者的限制。
为了满足我们对简短易用的验证工具的要求，我们开发了直肠癌女性性功能评分。它以高敏感性捕捉到了从幸存直肠癌患者的角度来看女性性功能的基本问题。请观看视频摘要，网址：http://links.lww.com/DCR/A576。
