年龄相关的胰岛素原加工变化在糖尿病和非糖尿病的日本个体中。

Age-related changes of proinsulin processing in diabetic and non-diabetic Japanese individuals.

机构信息

Diabetes Center, Shin-Suma Hospital, Kobe, Japan.

Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

出版信息

Geriatr Gerontol Int. 2018 Jul;18(7):1046-1050. doi: 10.1111/ggi.13303. Epub 2018 Apr 17.

DOI:10.1111/ggi.13303

PMID:29665183

Abstract

AIM

The present study was carried out to examine whether the insulin secretory mechanism deteriorates during the aging process using the new intact proinsulin assay system in non-diabetic and diabetic individuals.

METHODS

A total of 172 participants were separated into four groups according to their age (<64 years and >65 years) and an association of type 2 diabetes; that is, 46 older diabetics (mean age 74.5 ± 6.2 years, glycated hemoglobin [National Glycohemoglobin Standardization Program] 7.5 ± 1.3%), 27 older non-diabetics (mean age 76.9 ± 7.5 years), 48 middle-aged diabetics (mean age 50.8 ± 10.4, glycated hemoglobin 7.8 ± 1.5%) and 51 middle aged non-diabetics (mean age 46.6 ± 13.0 years) participants were enrolled.

RESULTS

The proinsulin/insulin (PI/I) ratio of the diabetic group was higher than that of the non-diabetic group in the older group (0.19 ± 0.12 vs 0.11 ± 0.06, P = 0.002). In the middle-aged groups, the PI/I ratio of the diabetic group was higher than that of the non-diabetic group (0.16 ± 0.15 vs 0.09 ± 0.09, P = 0.003). Simple regression analysis showed that male sex (95% CI 0.02-0.01, P = 0.004), age (95% CI 0.00-0.002, P = 0.03), lower body mass index (95% CI -0.06 to 0.00, P = 0.02) and the presence of diabetes mellitus (95% CI 0.04-0.012, P < 0.0001) were significantly associated with the increase in the PI/I ratio. Multivariate regression analysis showed that male sex and age were the independent factors determining the increase in the PI/I ratio in the non-diabetic group. After adjusted for body mass index, the PI/I ratio correlated significantly with age only in the non-diabetic group (r = 0.5, P = 0.004).

CONCLUSIONS

The proinsulin processing system might deteriorate not only in diabetics, but also in non-diabetic Japanese individuals with age. Also, sex-related hormones can be protective for the proinsulin processing system. Geriatr Gerontol Int 2018; 18: 1046-1050.

摘要

目的

本研究旨在使用新的完整胰岛素原检测系统，在非糖尿病和糖尿病个体中，研究胰岛素分泌机制是否随年龄增长而恶化。

方法

根据年龄（<64 岁和>65 岁）和 2 型糖尿病的相关性，将 172 名参与者分为四组；即 46 名老年糖尿病患者（平均年龄 74.5±6.2 岁，糖化血红蛋白[全国糖化血红蛋白标准化计划]7.5±1.3%）、27 名老年非糖尿病患者（平均年龄 76.9±7.5 岁）、48 名中年糖尿病患者（平均年龄 50.8±10.4 岁，糖化血红蛋白 7.8±1.5%）和 51 名中年非糖尿病患者（平均年龄 46.6±13.0 岁）。

结果

老年组中，糖尿病组的胰岛素原/胰岛素（PI/I）比值高于非糖尿病组（0.19±0.12 比 0.11±0.06，P=0.002）。在中年组中，糖尿病组的 PI/I 比值高于非糖尿病组（0.16±0.15 比 0.09±0.09，P=0.003）。简单回归分析显示，男性（95%可信区间 0.02-0.01，P=0.004）、年龄（95%可信区间 0.00-0.002，P=0.03）、较低的体重指数（95%可信区间-0.06 至 0.00，P=0.02）和糖尿病（95%可信区间 0.04-0.012，P<0.0001）与 PI/I 比值升高显著相关。多元回归分析显示，男性和年龄是非糖尿病组 PI/I 比值升高的独立因素。调整体重指数后，非糖尿病组 PI/I 比值与年龄呈显著正相关（r=0.5，P=0.004）。