环孢素A对大鼠慢性血清病肾炎诱导的抑制作用。

Suppressive effect of cyclosporin A on the induction of chronic serum sickness nephritis in the rat.

作者信息

Shigematsu H, Koyama A

机构信息

Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Acta Pathol Jpn. 1988 Jan;38(1):11-9. doi: 10.1111/j.1440-1827.1988.tb01068.x.

DOI:10.1111/j.1440-1827.1988.tb01068.x

PMID:2966540

Abstract

The suppressive effect of cyclosporin A (CyA) on the development of antibody-induced glomerulonephritis was analyzed in rats with serum sickness nephritis. The induction of serum sickness was established by preimmunization and subsequent continuous administration of the same antigen starting 1 month later. When CyA was given in the preimmunization stage, neither induction of glomerulonephritis nor specific antibody response was observed. In contrast, when CyA was administered in the stage of continuous sensitization, mild glomerulonephritis as well as specific antibody response developed. This phenomenon implies that the significant inhibition of the occurrence of immune complex nephritis results from the suppression by CyA of its primary response to the sensitizing antigen.

摘要

在血清病肾炎大鼠中分析了环孢素A（CyA）对抗体诱导的肾小球肾炎发展的抑制作用。通过预先免疫并在1个月后开始连续给予相同抗原建立血清病。当在预先免疫阶段给予CyA时，未观察到肾小球肾炎的诱导或特异性抗体反应。相反，当在持续致敏阶段给予CyA时，出现了轻度肾小球肾炎以及特异性抗体反应。这一现象表明，免疫复合物性肾炎发生的显著抑制是由于CyA对致敏抗原的初次反应的抑制所致。