采用倾向性评分评估妊娠相关性乳腺癌的预后：来自法国癌症网络的分析。
Propensity score to evaluate prognosis in pregnancy-associated breast cancer: Analysis from a French cancer network.
机构信息
Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Faculté de Médecine Sorbonne Université, Institut Universitaire de Cancérologie (IUC), France; Centre CALG (Cancer Associé à La Grossesse), France.
Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Faculté de Médecine Sorbonne Université, Institut Universitaire de Cancérologie (IUC), France; Centre CALG (Cancer Associé à La Grossesse), France.
出版信息
Breast. 2018 Aug;40:10-15. doi: 10.1016/j.breast.2018.03.014. Epub 2018 Apr 14.
PURPOSE
To compare the prognosis of pregnancy associated breast cancer occurring during pregnancy (BCP) to non-pregnancy associated breast cancers (non-BCP) in young women managed at a national expert center.
METHODS
Retrospective cohort study of a prospective database using propensity score matching (PSM) analysis with known prognostic factors.
RESULTS
We analyzed data of 49 patients with BCP and 104 with non-BCP diagnosed between 2002 and 2017 at Tenon University Hospital (Paris, France). The BCP tumors were often locally advanced (lymph node metastases in 59%), of high grade (55%) and highly proliferative (67% with Ki67 ≥ 20%). After PSM, breast cancer-free survival (p = 0.45) and breast cancer specific survival (p = 0.81) were similar in the two groups. The recurrence rate was 12% vs 18% (p = 0.45) and the death rate was 6% vs 8% (p = 0.74) for the BCP and non-BCP groups, respectively. No difference in recurrence type was observed between the groups (p = 0.60).
CONCLUSIONS
After PSM for known prognostic factors, the prognosis of BCP patients did not differ from that of young patients with non-BCP.
目的
比较在全国性专家中心治疗的年轻女性中妊娠相关乳腺癌（BCP）与非妊娠相关乳腺癌（non-BCP）的预后。
方法
使用倾向评分匹配（PSM）分析对 2002 年至 2017 年间在法国 Tenon 大学医院诊断为 BCP 和 non-BCP 的 49 例和 104 例患者进行回顾性队列研究，使用已知预后因素的前瞻性数据库。
结果
我们分析了 49 例 BCP 患者和 104 例 non-BCP 患者的数据，这些患者均于 2002 年至 2017 年在法国 Tenon 大学医院（巴黎）诊断。BCP 肿瘤通常局部晚期（淋巴结转移 59%），高分级（55%）和高增殖性（Ki67≥20% 的 67%）。经过 PSM 后，两组的无乳腺癌生存（p=0.45）和乳腺癌特异性生存（p=0.81）相似。BCP 组和 non-BCP 组的复发率分别为 12%和 18%（p=0.45），死亡率分别为 6%和 8%（p=0.74）。两组间复发类型无差异（p=0.60）。
结论
在对已知预后因素进行 PSM 后，BCP 患者的预后与年轻的 non-BCP 患者无差异。
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