Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China.
Int Immunopharmacol. 2018 Jun;59:227-232. doi: 10.1016/j.intimp.2018.04.019. Epub 2018 Apr 14.
Dickkopf-1 (DKK-1) is an endogenous inhibitor of canonical Wnt pathway that was implicated in the pathogenesis of rheumatoid arthritis (RA), but the serum levels of DKK-1 in RA were inconsistent among studies. Therefore, we conducted a meta-analysis to systematically evaluate the relationship between serum DKK-1 levels and RA.
PubMed, Web of Science and Cochrane Library were comprehensively retrieved till 1 January 2018 for pertinent studies. The pooled standard mean differences (SMDs) of serum DKK-1 levels were calculated according to the random effects model.
Nine original studies containing 1305 RA patients and 504 healthy controls were included in the meta-analysis. The pooled SMD of serum DKK-1 between RA patients and healthy controls was 0.79 (95% CI = 0.11 to 1.48, Z = 2.28 and P = 0.023), indicating a significantly higher serum level of DKK-1 in RA patients.
Serum level of DKK-1 is elevated in patients with RA compared to healthy controls, suggesting an important role of DKK-1 in the pathogenesis and treatment of RA.
Dickkopf-1（DKK-1）是经典 Wnt 通路的内源性抑制剂，与类风湿关节炎（RA）的发病机制有关，但 DKK-1 血清水平在不同研究中并不一致。因此，我们进行了一项荟萃分析，以系统评估 DKK-1 血清水平与 RA 之间的关系。
全面检索了 PubMed、Web of Science 和 Cochrane Library 数据库，以获取截止 2018 年 1 月 1 日的相关研究。根据随机效应模型计算 DKK-1 血清水平的合并标准均数差（SMD）。
纳入了 9 项原始研究，共包含 1305 例 RA 患者和 504 名健康对照者。RA 患者与健康对照组间 DKK-1 血清水平的合并 SMD 为 0.79（95%CI=0.11 至 1.48，Z=2.28，P=0.023），表明 RA 患者的 DKK-1 血清水平显著升高。
与健康对照者相比，RA 患者的 DKK-1 血清水平升高，提示 DKK-1 在 RA 的发病机制和治疗中具有重要作用。
