Abe K, Kogure K, Watanabe T
Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
J Cereb Blood Flow Metab. 1988 Jun;8(3):436-9. doi: 10.1038/jcbfm.1988.81.
The effect of PN200-110, a novel calcium antagonist, on the formation of brain edema was examined with rats using a middle cerebral artery (MCA) occlusion model. PN200-110 was effective in preventing the formation of brain edema in 6-h ischemia and in 3-h reperfusion following 3-h ischemia, which were cases in which great accumulations of calcium were autoradiographically observed. Furthermore, PN200-110 diminished the excessive accumulation of calcium in the MCA area involved. These results indicate that an inhibition of the massive influx of calcium into brain cells by PN200-110 may partially ameliorate cell damage, resulting in prevention of brain edema.
使用大鼠大脑中动脉（MCA）闭塞模型，研究了新型钙拮抗剂PN200 - 110对脑水肿形成的影响。PN200 - 110在预防6小时缺血以及3小时缺血后3小时再灌注过程中脑水肿的形成方面有效，在这些情况下，通过放射自显影观察到大量钙积累。此外，PN200 - 110减少了受累MCA区域钙的过度积累。这些结果表明，PN200 - 110抑制钙大量流入脑细胞可能部分改善细胞损伤，从而预防脑水肿。
