Schaff Z, Rácz K, Gutkowska J, Sergev O, Kiss R, Varga I, Szabó Z, Szende B, Lapis K, Fehér J
First Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
J Exp Pathol. 1987;3(3):229-42.
Using the immunoperoxidase method with specific antibody, we examined the presence of atrial natriuretic peptide (ANP) in adrenal tissues of a patient with primary aldosteronism and those derived from a patient with Cushing's syndrome. We found cells immunopositive for ANP in primary aldosteronism but not in Cushing's syndrome. In primary aldosteronism, we noted positively stained cells mainly but not exclusively in the adenomatous tissue. These results demonstrate for the first time the presence of immunoreactive ANP in adrenal tissues of a patient with primary aldosteronism and suggest that adrenal ANP may have potentially important impacts on aldosterone secretion in this disorder.
我们使用特异性抗体的免疫过氧化物酶方法，检测了一名原发性醛固酮增多症患者以及一名库欣综合征患者肾上腺组织中的心钠素（ANP）。我们发现原发性醛固酮增多症患者的肾上腺组织中有ANP免疫阳性细胞，而库欣综合征患者的肾上腺组织中则没有。在原发性醛固酮增多症中，我们注意到主要但并非仅在腺瘤组织中有阳性染色细胞。这些结果首次证明了原发性醛固酮增多症患者肾上腺组织中存在免疫反应性ANP，并表明肾上腺ANP可能对该疾病的醛固酮分泌有潜在的重要影响。
