术前皮下注射西地那非可提高大鼠随意皮瓣的存活率。
Preoperative subcutaneous sildenafil injection increases random flap survival in rats.
作者信息
Serin Merdan, Altinel Dincer, Leblebici Cem, Biltekin Burcu, Celikten Mert, Irmak Fatih, Yazar Sevgi Kurt
机构信息
Department of Plastic and Reconstructive Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.
出版信息
Acta Cir Bras. 2018 Mar;33(3):216-222. doi: 10.1590/s0102-865020180030000003.
PURPOSE
To investigate the effect of subcutaneous sildenafil on random flap survival.
METHODS
Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study. Rats in the sildenafil group received subcutaneous sildenafil injections daily for seven days before flap elevation. At the end of the treatment period, 9x3 cm dorsal skin flaps were elevated and reinserted back into their place in all of the animals. Necrotic and whole flaps areas were recorded on graph papers. Seven days after the flap elevation samples for histological examination were taken and angiographies were performed to visualize the flap vascularization.
RESULTS
The calculated average percentage of necrotic flap areas were 18.29% and 42.26% in the sildenafil and control group respectively.(p=0.0233). In selected angiography images, vessels were found to be more prominent in the sildenafil group. The average number of capillary formations under light microscopy was higher in the sildenafil group (p= 0.0286).
CONCLUSION
The subdermal high dose sildenafil has a positive effect on flap survival.
目的
探讨皮下注射西地那非对随意皮瓣存活的影响。
方法
将14只Wistar大鼠分为两组用于本实验研究。西地那非组大鼠在皮瓣掀起前连续7天每日皮下注射西地那非。在治疗期结束时，对所有动物掀起9×3 cm的背部皮瓣并将其重新放回原位。在方格纸上记录坏死皮瓣面积和整个皮瓣面积。皮瓣掀起7天后，取组织样本进行组织学检查，并进行血管造影以观察皮瓣血管化情况。
结果
西地那非组和对照组计算得出的坏死皮瓣面积平均百分比分别为18.29%和42.26%。（p = 0.0233）。在选定的血管造影图像中，发现西地那非组的血管更明显。西地那非组在光学显微镜下的毛细血管形成平均数更高（p = 0.0286）。
结论
皮下高剂量西地那非对皮瓣存活有积极作用。
Zotero 插件