慢性鞘内插管会影响下丘脑β-内啡肽和甲硫氨酸脑啡肽的浓度。

Chronic intrathecal cannulation affects hypothalamic beta-endorphin and met-enkephalin concentrations.

作者信息

Rovati L C, Sacerdote P, Bianchi M, Panerai A E

机构信息

Department of Pharmacology, School of Medicine, University of Milano, Italy.

出版信息

J Pharmacol Methods. 1988 Mar;19(1):85-8. doi: 10.1016/0160-5402(88)90048-4.

DOI:10.1016/0160-5402(88)90048-4

PMID:2966879

Abstract

Beta-endorphin concentrations decrease and met-enkephalin concentrations increase in the hypothalamus of rats bearing a chronic intrathecal cannula. The modification of the concentrations of beta-endorphin is already present on day 1 after surgery, whereas met-enkephalin is affected starting on day 6, and both peptides are still modified on day 10. These results indicate that chronically cannulated rats are not to be considered normal animals.

摘要

在植入慢性鞘内套管的大鼠下丘脑内，β-内啡肽浓度降低，而甲硫氨酸脑啡肽浓度升高。β-内啡肽浓度的改变在手术后第1天就已出现，而甲硫氨酸脑啡肽从第6天开始受到影响，并且两种肽在第10天仍有改变。这些结果表明，长期插管的大鼠不应被视为正常动物。