GoldiRunx 和记忆细胞毒性记忆。
GoldiRunx and Remembering Cytotoxic Memory.
机构信息
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunity. 2018 Apr 17;48(4):614-615. doi: 10.1016/j.immuni.2018.03.032.
The molecular basis for T cell memory differentiation remains elusive. Wang et al. (2018) identify Runx3 as an initiating transcription factor that specifies regulatory regions required for cytotoxic T cell (CTL) memory differentiation early after TCR signaling and constrains the ability of T-bet to drive terminal effector generation.
T 细胞记忆分化的分子基础仍然难以捉摸。Wang 等人（2018 年）确定 Runx3 是一种起始转录因子，它指定了 TCR 信号后早期 CTL 记忆分化所需的调节区，并限制了 T-bet 驱动终末效应器生成的能力。
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