HealthPartners Neuroscience Center, St Paul, Minnesota.
HealthPartners Institute, Bloomington, Minnesota.
J Int Neuropsychol Soc. 2018 Jul;24(6):646-651. doi: 10.1017/S1355617718000164. Epub 2018 Apr 19.
To examine neuropsychological test performance among individuals clinically diagnosed with Parkinson's disease (PD) without evidence of dopaminergic deficiency on [123]I-CIT single photon emission computed tomography imaging.
Data were obtained from the Parkinson's Progression Marker Initiative. The sample included 59 participants with scans without evidence of dopaminergic deficiency (SWEDD), 412 with PD, and 114 healthy controls (HC). Tests included Judgment of Line Orientation, Letter-Number Sequencing, Symbol Digit Modalities, Hopkins Verbal Learning Test-Revised, and Letter and Category Fluency. Multivariate analysis of variance was used to compare standardized scores between the groups.
There was a statistically significant difference in performances between the groups, F(14,1155)=5.04; p<.001; partial η2=.058. Pairwise comparisons revealed significant differences in Category Fluency between SWEDD (M=0.22; SD=1.08) and HC (M=0.86; SD=1.15) and in Symbol Digit Modalities Test performance between SWEDD (M=45.09; SD=11.54) and HC (M=51.75; SD=9.79). No significant differences between SWEDD and PD were found. Using established criteria, approximately one in four participants in the SWEDD and PD groups met criteria for mild cognitive impairment (MCI).
Individuals with SWEDD demonstrate significantly worse mental processing speed and semantic fluency than HC. The neuropsychological test performances and rates of MCI were similar between the SWEDD group and PD groups, which may reflect a common pathology outside of the nigrostriatal pathway. (JINS, 2018, 24, 646-651).
研究[123]I-CIT 单光子发射计算机断层扫描成像无多巴胺能缺陷的临床诊断为帕金森病（PD）个体的神经心理学测试表现。
数据来自帕金森病进展标志物倡议。样本包括 59 名无多巴胺能缺陷扫描证据（SWEDD）、412 名 PD 和 114 名健康对照（HC）参与者。测试包括直线定向判断、字母数字排序、符号数字模态、霍普金斯言语学习测试修订版和字母和类别流畅性。采用多元方差分析比较组间的标准化评分。
组间表现存在统计学显著差异，F（14，1155）=5.04；p<.001；部分η2=.058。两两比较显示，SWEDD（M=0.22；SD=1.08）与 HC（M=0.86；SD=1.15）之间的类别流畅性以及 SWEDD（M=45.09；SD=11.54）与 HC（M=51.75；SD=9.79）之间的符号数字模态测试表现存在显著差异。未发现 SWEDD 与 PD 之间存在显著差异。使用既定标准，SWEDD 和 PD 组中约四分之一的个体符合轻度认知障碍（MCI）标准。
SWEDD 个体的心理加工速度和语义流畅性明显低于 HC。SWEDD 组与 PD 组的神经心理学测试表现和 MCI 发生率相似，这可能反映了黑质纹状体通路以外的共同病理。（JINS，2018，24，646-651）。
