Abakumov G Z, Bushma M I, Lukienko P I, Legon'kova L F, Shurinov A S
Vopr Med Khim. 1988 Jan-Feb;34(1):39-41.
Nicotinamide (10-100 mM) caused a decrease in total "fast" flash of chemoluminescence, in rates of NADPH- and ascorbate dependent lipid peroxidation in microsomal fraction of rat liver tissue. Content of cytochrome P-450 (carbonyl complex) as well as rates of amidopyrine N-demethylation and aniline p-hydroxylation were also decreased in microsomal fraction. At the same time, inhibition of chemoluminescence was found after addition of 50, 100 mM nicotinamide to blood plasma or to solution of oxidized oleic acid. With an increase in nicotinamide concentration its inhibitory effect on lipid peroxidation was more distinct.
烟酰胺（10 - 100 mM）可使大鼠肝组织微粒体部分化学发光的总“快速”闪光减少，NADPH和抗坏血酸依赖性脂质过氧化速率降低。微粒体部分细胞色素P - 450（羰基复合物）的含量以及氨基比林N - 去甲基化和苯胺对羟基化的速率也降低。同时，向血浆或氧化油酸溶液中添加50、100 mM烟酰胺后，发现化学发光受到抑制。随着烟酰胺浓度的增加，其对脂质过氧化的抑制作用更加明显。
