采用正电子发射断层扫描（PET）研究儿童期亨廷顿舞蹈病患者的脑葡萄糖利用情况。

Brain glucose utilization in childhood Huntington's disease studied with positron emission tomography (PET).

作者信息

De Volder A, Bol A, Michel C, Cogneau M, Evrard P, Lyon G, Goffinet A M

机构信息

Positron Tomography Laboratory, University of Louvain, Louvain-la-Neuve, Belgium.

出版信息

Brain Dev. 1988;10(1):47-50. doi: 10.1016/s0387-7604(88)80046-9.

DOI:10.1016/s0387-7604(88)80046-9

PMID:2967038

Abstract

Brain glucose metabolism was measured in two children with early-onset Huntington's disease, using positron emission tomography with fluorodeoxyglucose (FDG) as the tracer. A marked (48%) hypometabolism was found at the level of the caudate nuclei, but other areas of the brain, particularly the cerebral cortex, were not significantly affected. Despite its different clinical presentation, Huntington's disease in children is characterized by brain metabolic alterations similar to those found in adult patients.

摘要

采用以氟脱氧葡萄糖（FDG）为示踪剂的正电子发射断层扫描技术，对两名早发性亨廷顿舞蹈症患儿的脑葡萄糖代谢进行了测量。结果发现，尾状核水平存在显著的（48%）代谢减退，但大脑的其他区域，尤其是大脑皮层，并未受到明显影响。尽管临床表现有所不同，但儿童亨廷顿舞蹈症的特征是脑代谢改变与成年患者相似。