V4+ T 细胞：在小鼠衣原体气道感染的早期阶段产生的新型白细胞介素-17 的 T 细胞亚群。
V4+ T Cells: A Novel IL-17-Producing T Subsets during the Early Phase of Chlamydial Airway Infection in Mice.
机构信息
Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Educational Ministry of China, Tianjin 300070, China.
出版信息
Mediators Inflamm. 2018 Feb 18;2018:6265746. doi: 10.1155/2018/6265746. eCollection 2018.
Our previous studies showed that T cells provided immune protection against Chlamydial (Cm), an obligate intracellular strain of chlamydia trachomatis, lung infection by producing abundant IL-17. In this study, we investigated the proliferation and activation of lung T cell subsets, specifically the IL-17 and IFN production by them following Cm lung infection. Our results found that five T cell subsets, V1+ T, V2+ T, V4+ T, V5+ T, and V6+ T, expressed in lungs of naïve mice, while Cm lung infection mainly induced the proliferation and activation of V4+ T cells at day 3 p.i., following V1+ T cells at day 7 p.i. Cytokine detection showed that Cm lung infection induced IFN secretion firstly by V4+ T cells at very early stage (day 3) and changed to V1+ T cells at midstage (day 7). Furthermore, V4+ T cell is the main T cell subset that secretes IL-17 at the very early stage of Cm lung infection and V1+ T cell did not secrete IL-17 during the infection. These findings provide in vivo evidence that V4+T cells are the major IL-17 and IFN-producing T cell subsets at the early period of Cm lung infection.
我们之前的研究表明，T 细胞通过产生大量的 IL-17 提供针对衣原体（Cm）的免疫保护，Cm 是一种专性细胞内沙眼衣原体。在这项研究中，我们研究了肺 T 细胞亚群的增殖和活化，特别是在 Cm 肺部感染后它们产生的 IL-17 和 IFN。我们的结果发现，在未感染的小鼠肺部表达了五种 T 细胞亚群，V1+T、V2+T、V4+T、V5+T 和 V6+T，而 Cm 肺部感染主要在感染后第 3 天诱导 V4+T 细胞的增殖和活化，随后在第 7 天诱导 V1+T 细胞。细胞因子检测显示，在早期（第 3 天），Cm 肺部感染首先诱导 V4+T 细胞分泌 IFN，然后在中期（第 7 天）转化为 V1+T 细胞。此外，在 Cm 肺部感染的早期，V4+T 细胞是主要分泌 IL-17 的 T 细胞亚群，而 V1+T 细胞在感染期间不分泌 IL-17。这些发现提供了体内证据，表明 V4+T 细胞是 Cm 肺部感染早期主要的产生 IL-17 和 IFN 的 T 细胞亚群。
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