Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes.

Four Zn(II) complexes containing a pyridyl triazine core (1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5',5″-disulfonic acid disodium salt and 2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl]·5HO·ZnCl (), [Zn(L1)Cl]·4HO·2CHOH (), [Zn(L2)Cl]·3HO·CHOH (), and [Zn(L2)Cl] (). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes - have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes - with bovine serum albumin (BSA) resulted binding constants () of 3.09 × 10 M, 12.30 × 10 M, and 16.84 × 10 M for ferene, complex , and complex , respectively, indicating potent serum distribution via albumins.