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新型磺化锌 - 三嗪配合物的合成、表征及与牛血清白蛋白的结合研究

Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes.

作者信息

Abeydeera Nalin, Perera Inoka C, Perera Theshini

机构信息

Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Department of Zoology and Environmental Science, University of Colombo, Colombo, Sri Lanka.

出版信息

Bioinorg Chem Appl. 2018 Feb 18;2018:7563820. doi: 10.1155/2018/7563820. eCollection 2018.

DOI:10.1155/2018/7563820
PMID:29670646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5835287/
Abstract

Four Zn(II) complexes containing a pyridyl triazine core (1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5',5″-disulfonic acid disodium salt and 2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4',4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl]·5HO·ZnCl (), [Zn(L1)Cl]·4HO·2CHOH (), [Zn(L2)Cl]·3HO·CHOH (), and [Zn(L2)Cl] (). The synthesized complexes are water soluble, making them good candidates for biological applications. All four complexes have been characterized by elemental analysis and H NMR, IR, and UV-Vis spectroscopy. The IR stretching frequency of N=N and C=N bonds of complexes - have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes. The binding studies of ligands and complexes - with bovine serum albumin (BSA) resulted binding constants () of 3.09 × 10 M, 12.30 × 10 M, and 16.84 × 10 M for ferene, complex , and complex , respectively, indicating potent serum distribution via albumins.

摘要

合成了四种含有吡啶基三嗪核心的锌（II）配合物（1 = 3-(2-吡啶基)-5,6-二(2-呋喃基)-1,2,4-三嗪-5',5″-二磺酸钠盐，2 = 3-(2-吡啶基)-5,6-二苯基-1,2,4-三嗪-4',4″-二磺酸钠盐），其化学式最终确定为[Zn(L1)Cl]·5H₂O·ZnCl₂（）、[Zn(L1)Cl]·4H₂O·2CH₃OH（）、[Zn(L2)Cl]·3H₂O·CH₃OH（）和[Zn(L2)Cl]（）。合成的配合物可溶于水，使其成为生物应用的良好候选物。所有四种配合物均通过元素分析以及¹H NMR、IR和UV-Vis光谱进行了表征。与游离配体相比，配合物 - 的N=N和C=N键的红外伸缩频率已移至较低频率，并且在所有四种配合物的UV-Vis光谱中均观察到红移。配体和配合物 - 与牛血清白蛋白（BSA）的结合研究结果表明，对于ferene、配合物 和配合物 ，结合常数（）分别为3.09×10⁴ M、1.23×10⁵ M和1.684×10⁵ M，表明通过白蛋白具有有效的血清分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/c1c3ee85806a/BCA2018-7563820.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/78ada1097723/BCA2018-7563820.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/ce16d2ac4bfa/BCA2018-7563820.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/afdcd25c2f26/BCA2018-7563820.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/11a08a607e96/BCA2018-7563820.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/483d4225a0e9/BCA2018-7563820.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/c1c3ee85806a/BCA2018-7563820.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/78ada1097723/BCA2018-7563820.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/ce16d2ac4bfa/BCA2018-7563820.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/afdcd25c2f26/BCA2018-7563820.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/11a08a607e96/BCA2018-7563820.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/483d4225a0e9/BCA2018-7563820.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5033/5835287/c1c3ee85806a/BCA2018-7563820.006.jpg

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