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与斑蝥素摄入相关的多发性动脉血栓形成

Multiple Arterial Thrombosis Related with Cantharidin Ingestion.

作者信息

Narli Ozdemir Zehra, Sahin Ugur, Civriz Bozdag Sinem, Ilhan Osman

机构信息

Department of Hematology, Faculty of Medicine, Ankara University, Ankara, Turkey.

出版信息

Case Rep Hematol. 2018 Feb 19;2018:8159093. doi: 10.1155/2018/8159093. eCollection 2018.

DOI:10.1155/2018/8159093
PMID:29670778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5836300/
Abstract

Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti-2 glycoprotein-I (anti-2-GPI) antibodies of IgA isotype.

摘要

遗传性和/或获得性血栓形成倾向缺陷可导致静脉或动脉血栓形成。本病例报告描述了一名46岁女性患者因摄入含有斑蝥素的壮阳药物引发动脉血栓事件,该患者后来被发现凝血酶原G20210A突变呈杂合子状态,且IgA同种型抗2糖蛋白-I(抗2-GPI)抗体呈血清阳性。

相似文献

1
Multiple Arterial Thrombosis Related with Cantharidin Ingestion.与斑蝥素摄入相关的多发性动脉血栓形成
Case Rep Hematol. 2018 Feb 19;2018:8159093. doi: 10.1155/2018/8159093. eCollection 2018.
2
The value of IgA antiphospholipid testing for diagnosis of antiphospholipid (Hughes) syndrome in systemic lupus erythematosus.IgA抗磷脂检测在系统性红斑狼疮抗磷脂(休斯)综合征诊断中的价值。
J Rheumatol. 2001 Dec;28(12):2637-43.
3
Thrombotic events in systemic lupus erythematosus. Its association with acquired and inherited thrombophilic defects.系统性红斑狼疮中的血栓形成事件。其与获得性和遗传性血栓形成倾向缺陷的关联。
Clin Hemorheol Microcirc. 2008;40(2):79-87.
4
Thrombophilic risk factors and homocysteine levels in Behçet's disease in eastern Spain and their association with thrombotic events.西班牙东部白塞病患者的血栓形成风险因素和同型半胱氨酸水平及其与血栓形成事件的关联
Thromb Haemost. 2006 Apr;95(4):618-24.
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Isotypes of anti-beta2-glycoprotein I antibodies: association with thrombosis in patients with systemic lupus erythematosus.抗β2糖蛋白I抗体的同种型:与系统性红斑狼疮患者血栓形成的关联
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Isotype distribution and clinical relevance of anti-beta2-glycoprotein I (beta2-GPI) antibodies: importance of IgA isotype.抗β2-糖蛋白I(β2-GPI)抗体的同种型分布及临床相关性:IgA同种型的重要性
Clin Exp Immunol. 1999 Sep;117(3):574-9. doi: 10.1046/j.1365-2249.1999.01007.x.
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Upper extremity deep vein thrombosis in a young patient double heterozygous for factor V Leiden and prothrombin G20210A mutation.
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Anti-beta2-glycoprotein I: prevalence, clinical correlations, and importance of persistent positivity in patients with antiphospholipid syndrome and systemic lupus erythematosus.抗β2糖蛋白I:抗磷脂综合征和系统性红斑狼疮患者中的患病率、临床相关性及持续阳性的重要性
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Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives.凝血酶原G20210A变异体和因子V莱顿突变携带者发生静脉血栓形成的风险及其与口服避孕药的相互作用。
Haematologica. 2000 Dec;85(12):1271-6.
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Prothrombin G20210A gene mutation, heparin cofactor II defects, primary (essential) thrombocythemia, and thrombohemorrhagic manifestations.凝血酶原G20210A基因突变、肝素辅因子II缺陷、原发性(特发性)血小板增多症及血栓出血表现。
Semin Thromb Hemost. 1999;25(4):375-86. doi: 10.1055/s-2007-994941.

本文引用的文献

1
Acute kidney injury by cantharidin poisoning following a silly bet on an ugly beetle.因对一只丑陋甲虫进行愚蠢打赌后斑蝥素中毒导致的急性肾损伤。
Clin Kidney J. 2013 Apr;6(2):201-3. doi: 10.1093/ckj/sft001.
2
Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study.无症状携带者中持续性抗磷脂抗体(aPL)作为未来血栓形成事件的危险因素:一项全国性前瞻性研究。
Lupus. 2014 Dec;23(14):1468-76. doi: 10.1177/0961203314545410. Epub 2014 Aug 27.
3
Drug-induced lupus anticoagulants and antiphospholipid antibodies.药物诱导性狼疮抗凝物和抗磷脂抗体。
Curr Rheumatol Rep. 2012 Feb;14(1):71-8. doi: 10.1007/s11926-011-0227-1.
4
Common risk factors for both arterial and venous thrombosis.动脉和静脉血栓形成的常见危险因素。
Br J Haematol. 2008 Mar;140(5):488-95. doi: 10.1111/j.1365-2141.2007.06973.x.
5
Cantharidin revisited: a blistering defense of an ancient medicine.斑蝥素再审视:对一种古老药物的热烈辩护
Arch Dermatol. 2001 Oct;137(10):1357-60. doi: 10.1001/archderm.137.10.1357.
6
Hereditary thrombophilia and venous thromboembolism.遗传性血栓形成倾向与静脉血栓栓塞症
Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1369-73. doi: 10.1164/ajrccm.158.5.9712022.
7
Prothrombin gene G20210-->A transition is a risk factor for cerebral venous thrombosis.凝血酶原基因G20210→A突变是脑静脉血栓形成的一个危险因素。
Stroke. 1998 Sep;29(9):1765-9. doi: 10.1161/01.str.29.9.1765.
8
Poisoning from "Spanish fly" (cantharidin).“西班牙苍蝇”(斑蝥素)中毒
Am J Emerg Med. 1996 Sep;14(5):478-83. doi: 10.1016/S0735-6757(96)90158-8.