Section of Functional and Reconstructive Urology, Department of Urology, Royal Hallamshire Hospital, Sheffield, UK.
University of Dammam, Dammam, Saudi Arabia.
BJU Int. 2018 Oct;122(4):673-679. doi: 10.1111/bju.14355. Epub 2018 May 10.
To describe the surgical approach and outcomes in the treatment of adult patients with complications of childhood hypospadias surgery, as such patients present a significant reconstructive challenge due to the combination of anatomical and cosmetic deformity, which often results in major functional and psychosexual sequelae.
We analysed prospectively collected data on 79 adults with complications of childhood hypospadias surgery, who were operated on between 2004 and 2016. Of the 79 patients, 48 underwent a two-stage urethroplasty using a buccal mucosa graft, and 31 underwent a one-stage distal urethroplasty.
Patients were followed up using flexible cystoscopy (every 6-9 months). The mean (range) follow-up was 48 (12-96) months. Of the 48 patients who underwent a two-stage repair, eight (16%) needed a revision of the first-stage graft. In total, nine of the 48 patients (16%) developed fistula requiring closure after the second stage; all but one was closed successfully on the first attempt, whilst one required two attempts before closure. Only two of the 48 patients that underwent a two-stage procedure required a re-do urethroplasty within 3 years. Of the 31 patients who underwent a one-stage repair, six (19%) needed fistula closure, all of which were successful. No patient required a further urethroplasty during follow-up.
Despite the significant surgical challenges found in this patient group, excellent long-term functional outcomes can be achieved. As expected there is a need for additional intervention, either for revision of the first stage or to close fistulae and less commonly for further reconstruction for stricture recurrence.
描述治疗儿童尿道下裂术后并发症的成年患者的手术方法和结果,因为这些患者由于解剖和美容畸形的结合,存在显著的重建挑战,这通常会导致严重的功能和性心理后遗症。
我们前瞻性分析了 2004 年至 2016 年间接受手术治疗的 79 例儿童尿道下裂术后并发症成年患者的临床资料。79 例患者中,48 例行颊黏膜移植两期尿道成形术,31 例行一期尿道远端成形术。
患者通过软式膀胱镜(每 6-9 个月一次)进行随访。平均(范围)随访时间为 48(12-96)个月。48 例行两期修复的患者中,8 例(16%)需要对第一期移植物进行修正。共有 48 例患者(16%)中,9 例发生瘘管,需要在第二期手术后关闭;除 1 例外,所有瘘管均首次成功关闭,其中 1 例需要两次尝试才能关闭。在 3 年内,仅 48 例行两期手术的患者中有 2 例需要再次进行尿道成形术。31 例行一期修复的患者中,6 例(19%)需要关闭瘘管,均成功。在随访期间,没有患者需要进一步的尿道成形术。
尽管在该患者群体中发现了重大的手术挑战,但可以实现出色的长期功能结果。正如预期的那样,需要进行额外的干预,无论是对第一期的修正还是关闭瘘管,较少情况下需要进一步重建以防止狭窄复发。