Gao Ran, Ren Meng, Li Yao, Cui Xing-Xing, Wang Jing
Sheng Li Ke Xue Jin Zhan. 2016 Apr;47(2):88-92.
Abdominal aortic aneurysm (AAA)is one of the most catastrophic arterial disease,with the severe outcome of sudden death due to the aortic rupture of weak arterial wall.Currently there is a lack of effective drug therapy for AAAs.Since the aging population situation is worsening,the prevalence of AAAs is rising constantly in China.There has already been plenty of factors known,which could led to AAA,however,the mechanism of AAA has not been very clearly.It has been recognized that many risk factors contribute to the development of AAA such as smoking,reactive oxygen species,matrix metallo-proteinase,and atherosclerosis,however,the mechanism of AAA formation has not been well under-stood.With the recent progressions in researches on inflammation and AAA,the role of inflammation in the pathogenesis of AAA has drawn increasing attention..This review will summarize recent advances in the investigations of leukocyte related mechanisms of aneurismal initiation and progression.
腹主动脉瘤（AAA）是最具灾难性的动脉疾病之一，由于薄弱的动脉壁发生主动脉破裂，会导致猝死这一严重后果。目前，对于腹主动脉瘤缺乏有效的药物治疗方法。随着人口老龄化情况日益严重，腹主动脉瘤在中国的患病率持续上升。虽然已知有许多因素可导致腹主动脉瘤，但腹主动脉瘤的发病机制尚未完全明确。人们已经认识到，许多风险因素会促使腹主动脉瘤的发展，如吸烟、活性氧、基质金属蛋白酶和动脉粥样硬化等，然而，腹主动脉瘤形成的机制尚未得到充分理解。随着近期炎症与腹主动脉瘤研究的进展，炎症在腹主动脉瘤发病机制中的作用受到了越来越多的关注。本综述将总结白细胞相关机制在动脉瘤起始和进展研究方面的最新进展。
