Rizvi Raheela Mohsin, Chughtai Novera Ghayoor, Kapadia Naheed
Department of Obstetrics and Gynecology, Aga Khan University Hospital, Karachi, Pakistan.
Department of Physiotherapy, Aga Khan University Hospital, Karachi, Pakistan.
Urol Int. 2018;100(4):420-427. doi: 10.1159/000488769. Epub 2018 Apr 19.
The purpose of our study was to see the efficacy of 3 different modes of treatment for overactive bladder (OAB) in symptoms reduction and quality of life improvement.
We conducted a 12-week single-blinded randomized controlled trial of women aged 22-65 years with clinical diagnosis of OAB. Arm A (n = 47) received bladder training, arm B (n = 50) received pelvic floor muscle training (PFMT), and arm C (n = 50) received PFMT with biofeedback. Bladder diary was used to assess the difference in urinary frequency, urgency, and leak accidents before and after treatment. Initial and final assessment was made using -validated urogenital distress inventory short form 6 (UDI-SF6) and incontinence impact questionnaire short form 7 (IIQ-SF7).
UDI-SF6 scores showed significant improvement in all arms. There was a reduction in UDI-6 scores from 8.38 ± 4.3 to 4.77 ± 5.5 with a mean difference of 3.61 ± 7.4 in patients in arm A (p = 0.002), arm B (p = 0.01), and arm C (p = 0.016). All patients in arms A, B, and C reported significant improvement in quality of life as assessed by IIQ-SF7 scores with significant p values of 0.009, 0.051, and 0.001, respectively. Bladder diary results using paired t test showed the significant difference in day time urinary frequency in arm A after treatment, as well as the reduction in both leak accidents and urgency score in all 3 arms.
All 3 arms of study showed significant results and can be used as the first line of management.
本研究旨在观察三种不同治疗方式对膀胱过度活动症(OAB)症状缓解及生活质量改善的疗效。
我们对年龄在22至65岁、临床诊断为OAB的女性进行了一项为期12周的单盲随机对照试验。A组(n = 47)接受膀胱训练,B组(n = 50)接受盆底肌肉训练(PFMT),C组(n = 50)接受带生物反馈的PFMT。使用膀胱日记评估治疗前后尿频、尿急和漏尿事故的差异。使用经过验证的泌尿生殖系统困扰量表简表6(UDI-SF6)和尿失禁影响问卷简表7(IIQ-SF7)进行初始和最终评估。
所有组的UDI-SF6评分均有显著改善。A组患者的UDI-6评分从8.38±4.3降至4.77±5.5,平均差异为3.61±7.4(p = 0.002),B组(p = 0.01)和C组(p = 0.016)。根据IIQ-SF7评分评估,A、B、C组所有患者的生活质量均有显著改善,p值分别为0.009、0.051和0.001。使用配对t检验的膀胱日记结果显示,A组治疗后白天尿频有显著差异,且所有三组的漏尿事故和尿急评分均有所降低。
研究的所有三组均显示出显著效果,可作为一线治疗方法。