Ghosh Moupali, Islam Nelofar, Saha Hinglaj, Mukhopadhyay Madhumita, Datta Chhanda, Saha Koushik, Chatterjee Uttara
Department of Pathology, IPGME&R, Kolkata, India.
Department of Pediatric Surgery, NRS Medical College, Kolkata, India.
Diagn Cytopathol. 2018 Sep;46(9):776-781. doi: 10.1002/dc.23950. Epub 2018 Apr 19.
Inflammatory myofibroblastic tumor is a tumor of intermediate grade with a low rate of metastasis. The tumor often mimics malignancy. There is sparse literature available describing the cytological findings of this rare condition. It often presents in infancy and childhood as an intra-abdominal mass. Here, we describe the cytological findings of three cases of inflammatory myofibroblastic tumor in infants aged 10 months, 4 months, and 15 months, respectively. While the first two cases are fine needle aspiration cytology (FNAC) smears, the third case is that of an intraoperative imprint cytology. All the three smears showed low cellularity with small clusters of bland spindle cells, along with sprinkling of inflammatory cells, suggestive of an inflammatory myofibroblastic tumor. The diagnosis was later confirmed on histopathology and positive immunostaining for ALK.
炎性肌纤维母细胞瘤是一种中度恶性肿瘤，转移率较低。该肿瘤常类似恶性肿瘤。关于这种罕见疾病的细胞学表现的文献较少。它在婴儿期和儿童期常表现为腹腔内肿块。在此，我们分别描述了3例年龄为10个月、4个月和15个月婴儿的炎性肌纤维母细胞瘤的细胞学表现。前两例为细针穿刺抽吸细胞学（FNAC）涂片，第三例为术中印片细胞学检查。所有3张涂片均显示细胞数量少，有小簇温和的梭形细胞，伴有散在的炎性细胞，提示炎性肌纤维母细胞瘤。诊断随后通过组织病理学和ALK免疫染色阳性得以证实。
