西班牙肺动脉高压住院患者的全国趋势和结局（2001-2014 年）。

National trends and outcomes of hospitalizations for pulmonary hypertension in Spain (2001-2014).

机构信息

Respiratory Department, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.

Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.

出版信息

Int J Cardiol. 2018 Jul 15;263:125-131. doi: 10.1016/j.ijcard.2018.04.026. Epub 2018 Apr 7.

DOI:10.1016/j.ijcard.2018.04.026

PMID:29673852

Abstract

OBJECTIVE

To assess changes in incidence, diagnostic procedures, comorbidity profiles, length of hospital stay (LOHS), costs, and in-hospital mortality (IHM) for patients hospitalized with pulmonary hypertension (PH).

METHODS

We included patients hospitalized with PH in Spain from 2001 to 2014. The data were collected from the National Hospital Discharge Database.

RESULTS

We included 644,436 discharges (43.31% males and 56.09% females) admitted for primary PH (8.34%) or secondary PH (91.66%). The crude incidence rate increased from 58.67 to 148.32 hospitalizations per 100,000 inhabitants between 2001 and 2002 and 2013-2014 (p < 0.001). The percentage of patients with a Charlson comorbidity index ≥2 was 27.87% in 2001-2002, increasing to 47.02% in 2013-2014 (p < 0.001). IHM was 8.77%, with a reduction in the value yielded by the multivariable analysis between 2009 and 2010 and 2013-2014. Median LOHS was 9 ± 9 days in 2001-2002, which decreased to 7 ± 8 days in 2013-2014 (p < 0.001). The mean cost per patient increased from €3352.4 ± €1495 in the period 2001-2002 to €4198.94 ± €1287.96 in 2013-2014 (p < 0.001).

CONCLUSIONS

Despite the increase over time in hospital admissions for PH, associated comorbidity, and costs, LOHS and IHM decreased, suggesting that the management of PH-related hospitalizations improved in Spain during the study period.

摘要

目的

评估 2001 年至 2014 年期间因肺动脉高压（PH）住院患者的发病率、诊断程序、合并症谱、住院时间（LOHS）、费用和院内死亡率（IHM）的变化。

方法

我们纳入了西班牙 2001 年至 2014 年因 PH 住院的患者。数据来自国家住院患者数据库。

结果

我们纳入了 644436 例（43.31%为男性，56.09%为女性）因原发性 PH（8.34%）或继发性 PH（91.66%）住院的患者。2001 年至 2002 年和 2013-2014 年之间，每 100000 居民中住院人数从 58.67 例增加到 148.32 例（p < 0.001），粗发病率增加。2001-2002 年，Charlson 合并症指数≥2 的患者比例为 27.87%，2013-2014 年增至 47.02%（p < 0.001）。IHM 为 8.77%，2009-2010 年和 2013-2014 年之间多变量分析的降幅降低。2001-2002 年，中位 LOHS 为 9±9 天，2013-2014 年降至 7±8 天（p < 0.001）。每位患者的平均费用从 2001-2002 年的 3352.4±1495 欧元增加到 2013-2014 年的 4198.94±1287.96 欧元（p < 0.001）。