School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Talanta. 2018 Jul 1;184:244-250. doi: 10.1016/j.talanta.2018.03.011. Epub 2018 Mar 8.
A new nanocomposite was developed based on reduced graphene oxide (RGO) supported gold dendrite and applied for amperometric detection of acetaminophen. The RGO-gold dendrite composite was prepared by self-assembly of poly (diallyldimethylammonium chloride) (PDDA) functionalized gold dendrite and poly (sodium 4-styrenesulfonate) (PSS) functionalized RGO. The composite electrode material was characterized by Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), Ultraviolet-vis spectroscopy (UV), X-ray diffraction (XRD), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The RGO-gold dendrite composite exhibited enhanced conductivity, catalytic activity and stability for acetaminophen oxidation and determination. The RGO-gold dendrite based electrochemical sensor is competent for detecting acetaminophen with a linear range from 0.07 µM to 3000 µM with a detection limit of 0.005 µM (S/N = 3). Moreover, the sensor was applied for the detection of acetaminophen in tablets and urine samples, which holds great promise in pharmaceutical analysis.
基于负载金树枝状大分子的还原氧化石墨烯纳米复合材料的构建及其对扑热息痛的电化学检测。通过聚二烯丙基二甲基氯化铵（PDDA）功能化的金树枝状大分子与聚（苯乙烯磺酸钠）（PSS）功能化的还原氧化石墨烯的自组装，制备了负载金树枝状大分子的还原氧化石墨烯复合材料。采用扫描电子显微镜（SEM）、能谱（EDS）、紫外可见光谱（UV）、X 射线衍射（XRD）、拉曼光谱和 X 射线光电子能谱（XPS）对复合材料进行了表征。负载金树枝状大分子的还原氧化石墨烯复合材料表现出增强的导电性、对扑热息痛氧化和测定的催化活性和稳定性。基于负载金树枝状大分子的电化学传感器对扑热息痛具有从 0.07µM 到 3000µM 的线性范围，检测限为 0.005µM（S/N=3）。此外，该传感器还用于片剂和尿液样品中扑热息痛的检测，在药物分析中具有广阔的应用前景。
