Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain.
Servicio de Digestivo, Hospital Virgen de la Salud, Toledo, Spain.
J Clin Virol. 2018 Jun;103:71-74. doi: 10.1016/j.jcv.2018.04.008. Epub 2018 Apr 12.
Host genetic background has been associated with liver fibrosis progression.
To analyze the association between the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism and liver fibrosis progression in hepatitis C virus (HCV)-infected patients.
In this retrospective cohort study, 187 patients with chronic HCV infection were included, who had at least two liver stiffness measurements (LSM) by transient elastography during the follow-up. Results were expressed in kilopascals (kPa). The analysis of genetic association was carried out according to additive model by using Generalized Linear Models.
No patients had advanced fibrosis/cirrhosis at baseline. During a median follow-up time of 47.9 months, 15 patients developed advanced fibrosis and 17 cirrhosis. In multivariate analysis adjusted by the main clinical and epidemiological covariates, the rs738409 G allele was related to higher increase of LSM values during the follow-up (adjusted arithmetic mean ratio (aAMR) = 1.16 (95%CI = 1.04; 1.29); p = .006) and higher odds of having progression to advanced fibrosis [aOR = 2.03 (95%CI = 1.01; 4.06); p = .045], and progression to cirrhosis [aOR = 3.03 (95%CI = 1.26; 7.30); p = .014].
PNPLA3 rs738409 polymorphism appears to be related to the increased progression of liver fibrosis in HCV infected patients.
宿主遗传背景与肝纤维化进展有关。
分析载脂蛋白样磷脂酶域包含蛋白 3（PNPLA3）rs738409 多态性与丙型肝炎病毒（HCV）感染患者肝纤维化进展的关系。
本回顾性队列研究纳入了 187 例慢性 HCV 感染患者，这些患者在随访期间至少有两次通过瞬时弹性成像进行的肝硬度测量（LSM）。结果以千帕斯卡（kPa）表示。根据加性模型，使用广义线性模型进行遗传关联分析。
基线时无患者存在晚期纤维化/肝硬化。在中位数为 47.9 个月的随访期间，15 例患者发展为晚期纤维化，17 例患者发展为肝硬化。在调整主要临床和流行病学协变量的多变量分析中，rs738409 G 等位基因与随访期间 LSM 值的更高增加相关（调整后的算术平均比（aAMR）= 1.16（95%CI = 1.04；1.29）；p = 0.006），并且进展为晚期纤维化的几率更高[aOR = 2.03（95%CI = 1.01；4.06）；p = 0.045]，进展为肝硬化的几率更高[aOR = 3.03（95%CI = 1.26；7.30）；p = 0.014]。
PNPLA3 rs738409 多态性似乎与 HCV 感染患者肝纤维化的进展增加有关。
