使用伊曲康唑治疗甲癣后发生的医源性子宫出血。

Iatrogenic metrorrhagia after the use of itraconazole for onychomycosis.

作者信息

Brzezinski Piotr, Gulin Sandra Jerkovic, Gulin Dario, Chiriac Anca

机构信息

Department of Dermatology, 6th Military Support Unit, Ustka, Poland.

Department of Dermatology and Venereology, General Hospital Sibenik, Sibenik, Croatia.

出版信息

Indian J Pharmacol. 2017 Nov-Dec;49(6):470-471. doi: 10.4103/ijp.IJP_838_16.

DOI:10.4103/ijp.IJP_838_16

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5892030/

Abstract

We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment.

摘要

我们报告首例关于伊曲康唑（一种常用于治疗甲癣的药物）与辛伐他汀联用导致子宫出血的病例。推测可能的机制是抑制类固醇生成，尤其是雌激素生成，从而导致低雌激素突破性出血。本文强调在开始甲癣治疗前进行药物相互作用检查的重要性。

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