Kabbara Wissam K, Meski Mohamad M, Ramadan Wijdan H, Maaliki Dina S, Salameh Pascale
Department of Pharmacy Practice, School of Pharmacy, Lebanese American University (LAU), Byblos, Lebanon.
School of Pharmacy, Lebanese American University (LAU), Byblos, Lebanon.
Can J Infect Dis Med Microbiol. 2018 Feb 20;2018:7404095. doi: 10.1155/2018/7404095. eCollection 2018.
The purpose of this study is to evaluate antibiotic-prescribing practices and adherence to IDSA guidelines for the treatment of uncomplicated urinary tract infections in Lebanon.
This observational prospective study was conducted in 15 community pharmacies in Lebanon over 1 year in adult females. A regimen of nitrofurantoin 100 mg bid for 5 days or fosfomycin 3 grams single dose were considered appropriate. For the bivariate analysis, the chi-square test was used.
A total of 376 patients were included in this study. The prescribed antibiotic was appropriate in 35 percent of the patients. Age (more than 50 years) did not significantly affect the appropriateness of the prescribed antibiotic (=0.508). The frequency of attacks per year (more than 3) negatively affected the choice of antibiotic (=0.025). The dose and duration of the prescribed antibiotic was appropriate in 73 and 58 percent of the patients, respectively, with a significant inappropriate dose and duration with fluoroquinolones as compared to nitrofurantoin and fosfomycin ( < 0.001 for the dose and =0.014 for the duration of therapy).
In an era of increasing bacterial resistance, interventions that improve physicians' prescribing practices for uncomplicated urinary tract infections are needed.
本研究旨在评估黎巴嫩治疗单纯性尿路感染时抗生素的处方情况以及对美国感染病学会（IDSA）指南的遵循情况。
这项观察性前瞻性研究在黎巴嫩的15家社区药房针对成年女性进行了为期1年的研究。将呋喃妥因100毫克每日两次服用5天或磷霉素3克单剂量的治疗方案视为合适方案。对于双变量分析，使用卡方检验。
本研究共纳入376名患者。35%的患者所开抗生素是合适的。年龄（超过50岁）对所开抗生素的合适性没有显著影响（P = 0.508）。每年发作次数（超过3次）对抗生素的选择有负面影响（P = 0.025）。所开抗生素的剂量和疗程分别在73%和58%的患者中是合适的，与呋喃妥因和磷霉素相比，氟喹诺酮类药物的剂量和疗程明显不合适（剂量P < 0.001，治疗疗程P = 0.014）。
在细菌耐药性不断增加的时代，需要采取干预措施来改善医生对单纯性尿路感染的处方行为。
