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茉莉酸响应转录因子调控植物次生代谢的研究进展

[Research progress of jasmonate-responsive transcription factors in regulating plant secondary metabolism].

作者信息

Yao Na, Jing Li, Zheng Han, Chen Min, Shen Ye

机构信息

State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Innovation Practice Center, Changchun University of Traditional Chinese Medicine, Changchun 130117, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 Mar;43(5):897-903. doi: 10.19540/j.cnki.cjcmm.20180109.001.

Abstract

Jasmonates, as a plant endogenous hormone, can induce the biosynthesis of terpenoids, alkaloids and flavonoids and other medicinal active ingredients, and play an important role in the plant secondary metabolic process. The tanscription factors can activate the expression of multiple genes in the biosynthesis of plant secondary metabolites by binding the cis-elements of the target genes. Then, it effectively activates or inhibits the activities of the enzymes on the biosynthesis of plant secondary metabolites, further regulate specific biosynthesis and accumulation of secondary metabolites. Here, We review recent major progresses regarding the regulation of secondary metabolites by JAs-responsive transcription factors (TFs) (including AP2/ERFs, bHLH, MYB and WRKY). That provides suggestions for further analysis of jasmonic acid signaling pathway and regulation of secondary metabolism, and explores the potential value of transcription factor in improving the medicinal active ingredients.

摘要

茉莉酸酯作为一种植物内源激素,能够诱导萜类、生物碱和黄酮类等药用活性成分的生物合成,并在植物次生代谢过程中发挥重要作用。转录因子可通过结合靶基因的顺式元件来激活植物次生代谢产物生物合成中多个基因的表达。进而有效激活或抑制植物次生代谢产物生物合成中酶的活性,进一步调控次生代谢产物的特定生物合成与积累。在此,我们综述了茉莉酸应答转录因子(包括AP2/ERF、bHLH、MYB和WRKY)对次生代谢产物调控的近期主要进展。这为进一步分析茉莉酸信号通路及次生代谢调控提供了建议,并探索转录因子在提高药用活性成分方面的潜在价值。

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